肿瘤相关巨噬细胞在头颈鳞状细胞癌中的作用及治疗策略研究进展

Research progress on role of tumor-associated macrophages in head and neck squamous cell carcinoma and its treatment strategies

肿瘤相关巨噬细胞(TAM)是肿瘤微环境中最重要的免疫细胞之一。已有研究证实,TAM具有高度可塑性,可随肿瘤微环境的变化而极化为免疫抑制的M2表型,在恶性肿瘤的发生、发展、侵袭和转移等阶段中发挥促进作用。大量文献表明TAM与头颈鳞状细胞癌(HNSCC)的不良预后相关,近年来关于靶向TAM治疗HNSCC的研究也逐渐深入,现就TAM在肿瘤发生、发展中的作用及靶向治疗策略做一综述。

Tumor-associated macrophages(TAM)are one of the most important immune cells in tumor microenvironment.The studies have confirmed that TAM has high plasticity and can be polarized into immunosuppressive M2 phenotype with the change of tumor microenvironment,which plays the promoting role in the occurrence,development,invasion and metastasis of various malignant tumors.A large number of literatures show that TAM is correlated with poor prognosis of head and neck squamous cell carcinoma(HNSCC).In recent years,the research on targeted TAM in the treatment of HNSCC has gradually deepened.This paper reviews the role of TAM in the occurrence and development of tumors and the targeted treatment strategies.