蛛网膜下腔出血早期脑损伤与铁死亡相关性的研究进展

Advances in correlation between early brain injury of subarachnoid hemorrhage and ferroptosis

铁死亡是一种铁依赖性的非凋亡性细胞死亡,是由铁过载引起细胞内脂质过氧化、活性氧蓄积,造成不可逆性细胞损伤的一种损伤模式。蛛网膜下腔出血(SAH)是一种具有高发病率和高死亡率的神经系统急症。近年研究报道早期脑损伤是SAH不良预后的重要因素,且铁死亡机制在SAH早期脑损伤中发挥重要作用。文章就铁死亡的3个主要机制氨基酸代谢、脂质过氧化和Fe^(2+)调控与SAH早期脑损伤的联系和主要调控靶点进行综述。

Ferroptosis,a form of non-apoptotic cell death,is characterized by iron dependent.It occurs when excessive ferrous ion causes intracellular lipid peroxidation and eventually leads to accumulation of reactive oxygen species,resulting in irreversible cell damage.Subarachnoid hemorrhage(SAH)is a neurological emergency with high morbidity and mortality.In recent years,it has been reported that early brain injury plays an important role for poor outcome of SAH,and ferroptosis is vital in early brain injury of SAH.In this review,amino acid metabolism,lipid peroxidation and Fe^(2+) regulation,three main mechanisms of ferroptosis and relative main regulatory targets were summarized in relation to early brain injury of SAH.