滋阴补阳方对多囊卵巢综合征患者性激素水平及排卵妊娠的影响研究

Effect of Ziyin Buyang Prescription on Levels of Sex Hormones,Ovulation and Pregnancy in Patients with Polycystic Ovary Syndrome

目的:观察滋阴补阳方对多囊卵巢综合征(PCOS)患者性激素水平及排卵妊娠的影响。方法:将200例PCOS排卵功能障碍性不孕症女性患者随机分为对照组与观察组各100例,其中对照组489个周期,有排卵周期383个,使用常规西药治疗;观察组492个周期,有排卵周期403个,在对照组基础上使用滋阴补阳方治疗。观察2组临床疗效,比较2组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)水平,记录促排卵周期人绒毛膜促性腺激素(HCG)用量、使用时间,统计卵泡发育情况、正常排卵周期、小卵泡周期、未破裂卵泡黄素化综合征(LUFS)周期、无反应取消周期、卵巢过度刺激综合征(OHSS)倾向、周期妊娠率和妊娠率。结果:观察组治疗总有效率78.00%,高于对照组62.00%(P<0.05)。与同组治疗前比较,治疗后2组血清FSH水平均升高(P<0.05),LH、T水平均降低(P<0.05);与对照组治疗后比较,观察组治疗后血清FSH水平较高(P<0.05),LH、T水平较低(P<0.05)。观察组治疗后HCG用量少于对照组(P<0.05),HCG使用时间短于对照组(P<0.05)。观察组无卵泡发育周期人数少于对照组(P<0.05),单卵泡和多卵泡发育周期人数多于对照组(P<0.05)。2组小卵泡周期比较,差异无统计学意义(P>0.05);观察组正常排卵周期多于对照组(P<0.05),LUFS周期少于对照组(P<0.05)。观察组取消周期、OHSS倾向周期均少于对照组(P<0.05),周期妊娠率及妊娠率均高于对照组(P<0.05)。2组治疗期间均未出现严重药物不良反应,轻微不良反应停药后均消失。结论:在常规西药基础上使用滋阴补阳方治疗PCOS患者,有较好的助孕效果,能在缩短HCG用药时间及用量的同时改善患者性激素水平及卵泡发育情况,同时提高患者正常排卵周期及妊娠率。

Objective:To observe the effect of the therapy of Ziyin Buyang prescription on levels of sex hormones,ovulation and pregnancy in patients with polycystic ovary syndrome(PCOS).Methods:A total of 200 PCOS female patients with infertility caused by ovulation dysfunction were randomly divided into the control group and the observation group,with 100 cases in each group.The control group,with 489 cycles and 383 ovulation cycles,was treated with the routine western medicine;the observation group,with 492 cycles and 403 ovulation cycles,was additionally treated with Ziyin Buyang prescription based on the treatment of the control group.The clinical effects in the two groups were observed.Before and after treatment,the levels of serum follicle stimulating hormone(FSH),luteinizing hormone(LH),and testosterone(T)were compared between the two groups.The dosage and time of the using of human chorionic gonadotropin(HCG)in ovulation induction cycle were recorded.The development of follicle,normal ovulation cycles,small follicle cycles,cycles with luteinized unruptured follicle syndrome(LUFS),cycles being cancelled due to no responses,tendency of ovarian hyperstimulation syndrome(OHSS),cycle pregnancy rates,and pregnancy rates were counted.Results:The total effective rate was 78.00%in the observation group,higher than that of 62.00%in the control group(P<0.05).After treatment,the levels of serum FSH in the two groups were increased when compared with those before treatment(P<0.05),and the levels of LH and T were decreased(P<0.05);after treatment,the level of serum FSH in the observation group was higher than that in the control group(P<0.05),and the levels of LH and T were lower(P<0.05).After treatment,the dosage of HCG in the observation group was less than that in the control group(P<0.05),and the time of HCG using was shorter(P<0.05).The number of patients with cycles of no follicular development in the observation group was smaller than that in the control group(P<0.05),and the number of patients with cycles of single or multi-follicular development was larger(P<0.05).There was no significant difference being found in the comparison of small follicle cycle between the two groups(P>0.05);there were more normal ovulation cycles in the observation group than in the control group(P<0.05),and there were less LUFS cycles in the observation group than in the control group(P<0.05).There were less cycles being cancelled due to no responses and less cycles with OHSS tendency in the observation group than in the control group(P<0.05),and the cycle pregnancy rate and pregnancy rate in the observation group were higher(P<0.05).No serious adverse reactions occurred in both groups during treatment,and mild adverse reactions disappeared after stopping treatment.Conclusion:The therapy of Ziyin Buyang prescription based on routine western medicine has a good effect of assisting pregnancy,which can shorten the time of using and dosage of HCG,improve the levels of sex hormones and follicular development,and increase the normal ovulation cycles and pregnancy rates of patients.