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五海瘿瘤丸联合左甲状腺素钠片治疗甲状腺腺瘤临床研究 被引量:3

Clinical Study on Wuhai Yingliu Pills Combined with Levothyroxine Sodium Tablets for Thyroid Adenoma
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摘要 目的:观察五海瘿瘤丸联合左甲状腺素钠片治疗甲状腺腺瘤的临床疗效。方法:回顾性选取180例甲状腺腺瘤患者,根据治疗方式不同分为对照组97例和观察组83例。对照组给予左甲状腺素钠片口服,观察组在对照组基础上加用五海瘿瘤丸治疗。比较2组治疗前后中医证候积分,检测治疗前、治疗1周、治疗1个月、治疗2个月后血清胰岛素样生长因子-1(IGF-1)、转化生长因子-β1(TGF-β1)、血管内皮生长因子(VEGF)水平,并统计2组不良反应发生率。结果:治疗前,2组颈部肿块、性情急躁、两胁胀痛、呼吸不利、胸闷评分及总分比较,差异无统计学意义(P>0.05)。治疗后,2组颈部肿块、性情急躁、两胁胀痛、呼吸不利、胸闷评分及总分较治疗前降低,且观察组各项评分及总分均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组IGF-1、TGF-β1及VEGF水平比较,差异无统计学意义(P>0.05)。治疗1周、治疗1个月、治疗2个月后,2组IGF-1、VEGF水平逐渐降低,且观察组IGF-1、VEGF水平均低于同时间点对照组(P<0.05);2组TGF-β1水平逐渐升高,且观察组TGF-β1水平高于同时间点对照组(P<0.05)。结论:五海瘿瘤丸联合左甲状腺素钠片治疗甲状腺腺瘤可显著改善患者临床症状,降低中医证候积分,降低血清IGF-1、VEGF水平并升高TGF-β1水平,且不会增加不良反应。 Objective:To observe the clinical effect of Wuhai Yingliu pills combined with levothyroxine sodium tablets for thyroid adenoma.Methods:A total of 180 cases of patients with thyroid adenoma were selected retrospectively and divided into the control group and the observation group according different treatment methods,with 97 and 83 cases in each group respectively.The control group was given the oral administration of levothyroxine sodium tablets,and the observation group was additionally treated with Wuhai Yingliu pills based on the treatment of the control group.Chinese medicine symptom scores before and after treatment in the two groups were compared.Levels of insulin-like growth factor-1(IGF-1),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in serum before treatment and after one week,one month and two months of treatments were detected.The incidence of adverse reactions in the two groups was counted.Results:Before treatment,there was no significant difference being found in the comparison of scores of neck mass,irritability,rib-side distending pain,poor breathing and chest tightness as well as the total scores between the two group(P>0.05).After treatment,scores of neck mass,irritability,rib-side distending pain,poor breathing and chest tightness as well as the total scores in the two groups were decreased when compared with those before treatment,and the scores in the observation group were lower than those in the control group,differences being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IGF-1,TGF-β1 and VEGF between the two groups(P>0.05).After one week,one month and two months of treatments,levels of IGF-1 and VEGF in the two groups were gradually decreased,and levels of IGF-1 and VEGF in the observation group were lower than those in the control group at the same time point(P<0.05);TGF-β1 levels in the two groups were gradually increased,and the level in the observation group was higher than that in the control group at the same time point(P<0.05).Conclusion:Wuhai Yingliu pills combined with levothyroxine sodium tablets for thyroid adenoma can significantly improve clinical symptoms,reduce Chinese medicine syndrome scores and levels of IGF-1 and VEGF in serum,and enhance TGF-β1 levels without any increase in adverse reactions.
作者 商建人 任雨芳 SHANG Jianren;REN Yufang
出处 《新中医》 CAS 2022年第13期147-150,共4页 New Chinese Medicine
关键词 甲状腺腺瘤 五海瘿瘤丸 左甲状腺素钠片 中医证候积分 胰岛素样生长因子-1 转化生长因子Β1 血管内皮生长因子 不良反应 Thyroid adenoma Wuhai Yingliu pills Levothyroxine sodium tablets Chinese medicine syndrome scores Insulin-like growth factor-1 Transforming growth factor-β1 Vascular endothelial growth factor Adverse reactions
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