滋肾抑阳消抗汤联合常规西药治疗肾虚血瘀型免疫性不孕的临床研究

Clinical Study on Zishen Yiyang Xiaokang Decoction Combined with Conventional Western Medicine in the Treatment of Immune Infertility of Kidney-Deficiency and Blood-Stasis Type

目的:探讨滋肾抑阳消抗汤联合常规西药治疗肾虚血瘀型免疫性不孕的临床疗效。方法:选取2018年1月至2019年11月淄博市中医医院收治的中医辨证为肾虚血瘀型的免疫性不孕患者88例,并按照随机数字表法分为对照组和研究组,各44例。对照组患者采用常规西药治疗,研究组患者采用滋肾抑阳消抗汤联合常规西药治疗。对比两组患者治疗前后中医症状评分,观察两组患者的临床疗效、血清免疫抗体转阴率、治疗后1年内的妊娠率以及治疗期间不良反应发生率。结果:治疗后,两组患者主症评分、次症评分、舌脉评分及总评分均低于治疗前,且研究组患者主症评分、次症评分、舌脉评分及总评分均低于对照组,差异均有统计学意义(P<0.05)。研究组患者的总有效率为93.18%(41/44),高于对照组的70.45%(31/44),差异有统计学意义(P<0.05)。研究组患者抗精子抗体转阴率、血清免疫抗体总转阴率和治疗后1年内的妊娠率均高于对照组,差异均有统计学意义(P<0.05);研究组与对照组患者抗子宫内膜抗体转阴率、抗心磷脂抗体转阴率和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:采用滋肾抑阳消抗汤联合常规西药治疗肾虚血瘀型免疫性不孕患者,能够减轻患者的临床症状,促进血清免疫抗体转阴,提高临床疗效和妊娠率,且安全性较好。

OBJECTIVE:To probe into the clinical effect of Zishen Yiyang Xiaokang decoction combined with conventional western medicine in the treatment of immune infertility of kidney-deficiency and blood-stasis type.METHODS:Totally 88 patients with immune infertility differentiated with kidney-deficiency and blood-stasis syndrome admitted in Zibo Hospital of Traditional Chinese Medicine from Jan.2018 to Nov.2019 were selected to be divided into the control group and the research group via the random number table,with 44 cases in each group.The control group was treated with conventional western medicine,while the research group was given Zishen Yiyang Xiaokang decoction combined with conventional western medicine.The traditional Chinese medicine(TCM)symptom scores was compared between two groups before and after treatment,the clinical efficacy,negative conversion rates of serum immune antibody,pregnancy rates within 1 year after treatment and incidences of adverse drug reactions during treatment were observed.RESULTS:After treatment,the primary symptom,secondary symptom,tongue pulse and total TCM scores of both groups were lower than before treatment,and those of the research group were lower than the control group,with statistically significant differences(P<0.05).The total effective rate of research group was 93.18%(41/44),which was higher than that of the control group(70.45%,31/44),with statistically significant difference(P<0.05).The negative conversion rate of AsAb,the total negative conversion rate serum immune antibody and the pregnancy rate within 1 year after treatment were higher in the research group than the control group,with statistically significant differences(P<0.05);there were no statistically significant differences in negative conversion rates of EmAb and AcAb,and the incidences of adverse drug reactions between research group and control group(P>0.05).CONCLUSIONS:The Zishen Yiyang Xiaokang decoction combined with conventional western medicine in the treatment of patients with immune infertility of kidney-deficiency and blood-stasis type can relieve clinical symptoms,promote negative conversion of serum immune antibody,improve clinical efficacy and pregnancy rate,with higher safety.