丹参注射液联合常规治疗对高血压患者炎症水平及心室重构的影响

Effects of Danshen Injection Combined with Routine Treatment on Inflammatory Levels and Ventricular Remodeling in Patients with Hypertension

目的:探讨丹参注射液联合常规治疗对高血压患者炎症水平及心室重构的影响。方法:选择2019年4月至2020年9月汕头潮南民生医院收治的100例高血压患者,采用随机数字表法分为对照组(常规降压治疗,50例)和研究组(在对照组常规降压治疗基础上接受丹参注射液治疗,50例),对比两组患者炎症因子、血压、Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核因子κB(NF-κB)通路相关蛋白及心室重构指标水平变化情况。结果:两组患者治疗结束后的收缩压、舒张压均较治疗前降低,且研究组患者低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗结束后的血清白细胞介素6、C反应蛋白和肿瘤坏死因子α水平均较治疗前降低,且研究组患者低于对照组,差异均有统计学意义(P<0.05)。治疗结束后,研究组患者室间隔厚度、左心室后壁厚度和左心室舒张末期内径均较治疗前降低,且低于对照组,差异均有统计学意义(P<0.05);对照组患者治疗前后上述指标水平的差异无统计学意义(P>0.05)。两组患者治疗结束后的TLR4、MyD88和NF-κB蛋白表达水平均较治疗前降低,且研究组患者低于对照组,差异均有统计学意义(P<0.05)。结论:丹参注射液联合常规治疗可有效降低高血压患者的血压,控制炎症因子水平,缓解心室重构,可能与调控TLR4/MyD88/NF-κB通路有关。

OBJECTIVE:To probe into the effects of Danshen Injection combined with routine treatment on inflammatory levels and ventricular remodeling in patients with hypertension.METHODS:Totally 100 patients with hypertension admitted into Shantou Chaonan Minsheng Hospital from Apr.2019 to Sept.2020 were extracted to be divided into the control group(routine antihypertensive treatment,50 cases)and the study group(Danshen injection on the basis of antihypertensive treatment in the control group,50 cases)via the random number table.The inflammatory factors,blood pressure and Toll like receptor 4(TLR4)/myeloid differentiation protein 88(MyD88)/nuclear factor-κB(NF-κB)were compared between two groups.RESULTS:After treatment,the systolic blood pressure and diastolic blood pressure in two groups were lower than those before treatment,the study group was lower than the control group,the differences were statistically significant(P<0.05).The levels of serum interleukin-6,C-reactive protein and tumor necrosis factorαin two groups after treatment were lower than those before treatment,the study group was lower than the control group,with statistically significant differences(P<0.05).After treatment,the ventricular septal thickness,left ventricular posterior wall thickness and left ventricular end-diastolic diameter in the study group were lower than those before treatment,the study group was lower than the control group,with statistically significant differences(P<0.05);there was no significant difference in the levels of above indicators in the control group before and after treatment(P>0.05).The expression levels of TLR4,MyD88 and NF-κB proteins in two groups after treatment were lower than those before treatment,the study group was lower than the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Danshen injection combined with conventional treatment can effectively reduce the blood pressure,control the level of inflammatory factors,and relieve ventricular remodeling in patients with hypertension,which may be related to the regulation of TLR4/MyD88/NF-κB pathway.