期刊文献+

复发性卵巢性索间质肿瘤的临床特点及预后因素 被引量:1

Clinical characteristics and prognostic factors of recurrent ovarian sex cord stromal tumor
原文传递
导出
摘要 目的:讨论复发性卵巢性索间质肿瘤(OSCST)患者的临床特点及预后相关因素。方法:2012年6月至2021年12月期间武汉大学中南医院共收治OSCST患者127例,对其中随访资料完整的12例复发性OSCST患者进行回顾性研究。结果:12例患者首次复发距初次治疗结束的中位无疾病进展期(PFS)为67.5(6~120)月,除2例仅复发一次外,其余10例患者均经历了2~6次不等的复发过程,总共有33次复发,多次复发的中位PFS为24(1~110)月,最终6例患者死亡,6例患者存活。通过Kaplan-Meier生存分析结果显示复发治疗后的治疗方式(P=0.001)、术后残余瘤(P=0.012)、复发治疗后可测量病灶(P=0.003)与肿瘤复发密切相关。COX多因素分析复发治疗后治疗方式、可测量病灶大小是复发患者的不良预后因素。结论:复发性OSCST患者需根据复发转移部位、残余肿瘤大小等病情严重程度不同选择适当的联合治疗方案,通过尽可能消灭复发转移病灶来延长患者PFS、缓解病情。 Objective:To investigate the clinical characteristics and prognostic factors of patients with recurrent ovarian sex cord stromal tumor(OSCST).Methods:From June 2012 to December 2021,127 patients with ovarian sex cord stromal tumors were treated in Zhongnan Hospital of Wuhan University.In this study,12 patients with recurrent OSCST with complete follow-up data were studied retrospectively.Results:The median progression-free survival(PFS)of the first recurrence from the end of initial treatment was 67.5 months(6-120 months)in the 12 patients.Except that 2 patients had only one recurrence,the other 10 patients experienced a recurrence process ranging from 2 to 6 times,a total of33 recurrences,and the median PFS for multiple recurrences was 24 months(1-110 months).Finally,6 patients died and 6 patients survived.The results of Kaplan-Meier survival analysis showed that treatment strategies(P=0.001),postoperative residual tumor(P=0.012),and measurable lesion after relapse treatment(P=0.003)were strongly associated with tumor recurrence.COX multifactorial analysis of treatment strategies,and measurable lesion size were independent prognostic factors for patients with relapse.Conclusion:In recurrent OSCST patients,choosing the appropriate combination therapy to eliminate the metastatic lesions will help to improve the treatment outcome and prognosis of patients.
作者 张帆 熊艳 芦玉兰 李蓁 ZHANG Fan;XIONG Yan;LU Yulan;LI Zhen(Dept.of Gynecology Oncology,Zhongnan Hospital of Wuhan University/Hubei Clinical Cancer Study Center/&Hubei Key Laboratory of Tumor Biological Behaviors,Wuhan 430071,Hubei,China)
出处 《武汉大学学报(医学版)》 CAS 2022年第4期628-633,共6页 Medical Journal of Wuhan University
关键词 卵巢性索间质肿瘤 复发 预后 临床效果 Ovarian Sex Cord Stromal Tumor Recurrent Prognosis Clinical Efficacy
  • 相关文献

同被引文献14

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部