尿液γ干扰素诱导蛋白10作为狼疮肾炎生物标志物的Meta分析

Urinary interferon-gamma induced protein 10 as a biomarker for lupus nephritis:A meta-analysis

目的:评价尿液γ干扰素诱导蛋白10(IP-10)在狼疮肾炎(LN)中的表达及其意义。方法:系统检索PubMed、The Cochrane Library、Embase、中国知网(CNKI)、万方医学网和维普数据库收录的中英文文献,同时手工检索纳入文献的参考文献。采用RevMan 5.4软件对LN患者中尿液IP-10的表达情况进行Meta分析,比较尿液IP-10在活动性LN组、非活动性LN组、健康对照组中的表达。结果:共纳入了9个研究,包括773例患者。Meta结果显示:(1)活动性LN组尿液IP-10表达水平明显高于非活动性LN组(SMD=2.25,95%CI:1.34~3.17,P<0.01);(2)活动性LN组尿液IP-10表达水平明显高于健康对照组(SMD=1.87,95%CI:0.95~2.79,P<0.01);(3)非活动性LN组尿液IP-10表达水平明显高于健康对照组(SMD=1.75,95%CI:0.33~3.17,P=0.02)。结论:IP-10是评价LN活动性与否的标志物,特别是在高加索人中;IP-10也是鉴别狼疮肾炎与健康对照的生物标志物,特别是在亚洲人中。

Objective:To evaluate the expression and significance of urinary interferon-gamma induced protein 10(IP-10)in lupus nephritis(LN).Methods:The English and Chinese literatures included in PubMed,The Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data and VIP Data were searched systematically,and the references were searched by hand.The expression of urinary IP-10 in LN patients was analyzed with RevMan 5.4.The expression of urinary IP-10 was compared among active LN group,inactive LN group,and healthy control group.Results:A total of 9 studies were included,including 773 patients.The results of Meta-analysis showed that the expression of urinary IP-10 in active LN group was significantly higher than that in inactive LN group(SMD=2.25,95%CI:1.34-3.17,P<0.01).The expression of urinary IP-10 in active LN group was significantly higher than that in healthy control group(SMD=1.87,95%CI:0.95-2.79,P<0.01).The expression of urinary IP-10 in inactive LN group was significantly higher than that of healthy control group(SMD=1.75,95%CI:0.33-3.17,P=0.02).Conclusion:IP-10 is a marker for evaluating the activity of LN,especially in Caucasians;IP-10 is also a biomarker for distinguishing lupus nephritis from healthy controls,especially in Asians.