醒脑静治疗急性酒精中毒的疗效评价

Efficacy of Xingnaojing in the treatment of acute alcoholism

目的分析醒脑静在急性酒精中毒治疗中的临床应用安全性及可靠性。方法抽取河南省人民医院2019年2月至2019年11月收治的100例急性酒精中毒患者作为研究对象,按随机数字表法分为常规组和研究组,每组50例。常规组单用纳洛酮治疗,研究组在纳洛酮基础上加用醒脑静治疗,比较两组的治疗效果及不良反应发生率。结果研究组的催醒时间为(1.61±0.36)h,临床症状消失时间为(3.41±1.16)h,均短于常规组的(3.45±0.46)、(6.26±2.36)h,P均<0.05;研究组治疗总有效率(94.0%,47/50)高于常规组(80.0%,40/50),P<0.05。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论急性酒精中毒患者应用醒脑静治疗,可促进其临床症状改善并提高临床疗效,且不增加患者不良反应的发生风险。

Objective To analyze the clinical safety and feasibility of Xingnaojing in the treatment of acute alcoholism.Methods One hundred patients with acute alcoholism treated in Henan Provincial People’s Hospital from February 2019 to November 2019 were selected as the research objects,and they were divided into routine group and study group according to random number table method,with 50 cases in each group.The routine group was treated with naloxone,and the study group was treated with Xingnaojing combined with naloxone.The therapeutic effect and adverse reaction were compared between the two groups.Results The wake-up time of the study group was(1.61±0.36)h,and the disappearance time of clinical symptoms was(3.41±1.16)h,which were shorter than(3.45±0.46)h and(6.26±2.36)h of the routine group(all P<0.05);the total effective rate of the study group(94.0%,47/50)was higher than that of the routine group(80.0%,40/50),P<0.05.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The application of Xingnaojing in patients with acute alcoholism can promote the improvement of clinical symptoms and improve clinical efficacy,without increasing the risk of adverse reactions.