精神分裂症外周血中BDNF、MIF、EGF水平及其与认知功能关系

Levels of BDNF,MIF and EGF in peripheral blood of patients with schizophrenia and their relationship with cognitive function

目的:探讨精神分裂症病人血清脑源性神经营养因子(BDNF)、巨噬细胞迁移抑制因子(MIF)、表皮生长因子(EGF)水平及其与认知功能关系。方法:选择54例精神分裂症病人作为观察组,另选取同期健康体检者58名作为对照组。采用酶联免疫吸附试验检测2组BDNF、MIF、EGF水平,阳性和阴性症状量表(posi tive and negative syndrome scale, PANSS)评估病人临床症状,认知功能成套测验共识版(MCCB)测评认知功能,Pearson直线相关分析评价血清BDNF、MIF、EGF水平与认知功能关系。结果:观察组BDNF水平明显低于对照组(P<0.01),MIF、EGF水平明显高于对照组(P<0.01)。BDNF水平与PNASS评分呈负相关关系(P<0.05),MIF水平与PNASS评分呈正相关关系(P<0.05),EGF水平与PANSS评分无明显相关性(P>0.05)。观察组连线测验评分明显高于对照组(P<0.01),符号编码、视觉记忆、言语记忆和语义流畅性评分均明显低于观察组(P<0.01)。观察组血清MIF、EGF水平与视觉空间记忆均呈正相关关系(P<0.05)。结论:精神分裂症病人血清MIF、EGF水平与其临床表现和部分认知功能障碍密切相关。

Objective:To investigate the serum levels of brain-derived neurotrophic factor(BDNF),macrophage migration inhibitory factor(MIF) and epidermal growth factor(EGF) in patients with schizophrenia and their relationship with cognitive function.Methods:A total of 54 patients with schizophrenia were selected as the observation group, and 58 healthy people in the same period were selected as the control group.The levels of BDNF,MIF and EGF were detected by enzyme-linked immunosorbent assay, the patient′s clinical symptoms were evaluated by positive and negative syndrome scale(PANSS),the cognitive function was assessed by MATRICS consensus cognitive battery(MCCB),and the relationship between serum BDNF,MIF,EGF levels and cognitive function was evaluated by Pearson linear correlation analysis.Results:The level of BDNF in observation group was significantly lower than that in control group(P<0.01),and the levels of MIF and EGF were significantly higher than those in control group(P<0.01).BDNF level was negatively correlated with PNASS score(P<0.05),MIF level was positively correlated with PNASS score(P<0.05),and EGF level was not significantly correlated with PANSS score(P>0.05).The scores of connection test in observation group were significantly higher than those in control group(P<0.01),and the scores of symbol coding, visual memory, verbal memory and semantic fluency in observation group were significantly lower than those in control group(P<0.01).The serum levels of MIF and EGF in observation group were positively correlated with visual spatial memory(P<0.05).Conclusions:The serum levels of MIF and EGF are closely related to the clinical manifestations and some cognitive impairments in patients with schizophrenia.