血小板淋巴细胞比值、中性粒淋巴细胞比值与胆源性急性胰腺炎病人预后的关系

Relationship between platelet to lymphocyte ratio,neutrophil to lymphocyte ratio and prognosis of patients with biliogenic acute pancreatitis

目的:研究血小板淋巴细胞比值(PLR)、中性粒淋巴细胞比值(NLR)与胆源性急性胰腺炎病人预后关系,并比较二者在预测胆源性急性胰腺炎预后中的价值。方法:回顾性分析2015年1月至2020年1月338例首诊的胆源性急性胰腺炎病人临床资料,利用受试者工作特征曲线(ROC)得出PLR与NLR最佳界值;比较不同水平PLR和NLR病人的临床特征,分析胆源性急性胰腺炎预后的危险因素。结果:以生存状态为依据PLR最佳界值为344.7,NLR的最佳界值为17.8。PLR的ROC曲线下面积(AUC)大于NLR(Z=2.03,P<0.05)。多因素Cox回归模型表明,低PLR病人死亡风险是高PLR病人死亡风险的3.551倍(95%CI:1.161~10.868);高NLR病人死亡风险是低NLR病人死亡风险的2.769倍(95%CI:1.039~7.397)。结论:PLR和NLR可能与胆源性急性胰腺炎预后相关。与NLR相比,PLR预测急性胰腺炎预后更加准确。

Objective:To study the relationship between platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR)and the prognosis of patients with biliogenic acute pancreatitis,and to compare their value in predicting the prognosis of biliogenic acute pancreatitis.Methods:The clinical data of 338 patients with biliogenic acute pancreatitis diagnosed first time from January 2015 to January 2020 were retrospectively reviewed.Receiver operating curve(ROC)was used to determine the best critical value of PLR and NLR.The clinical features of patients with different levels of PLR and NLR were compared and the prognostic risk factors of biliogenic acute pancreatitis were explored.Results:The best critical values of PLR and NLR were 344.7 and 17.8,respectively according to the survival status of patients.The area under ROC curve(AUC)of PLR was bigger than NLR(Z=2.03,P<0.05).Multivariate Cox regression model showed that the death risk of patients with low PLR was 3.551 times higher than that in patients with high PLR(95%CI:1.161-10.868),and the risk of death in patients with high NLR was 2.769 times higher than that in patients with low NLR(95%CI:1.039-7.397).Conclusions:PLR and NLR may be related to the prognosis of biliogenic acute pancreatitis.Compared with NLR,PLR is more accurate in predicting the prognosis of biliogenic acute pancreatitis.