新生儿脑损伤与围生期感染关联性的Meta分析

The correlation between neonatal brain damage and perinatal infection:A Meta-analysis

目的运用Meta分析系统评价新生儿脑损伤与围生期感染关联性,明确脑损伤的病因,以尽早对脑损伤新生儿进行干预及治疗,改善其远期预后。方法检索的数据库包括:CBM、知网、维普、万方、PubMed、Web of Science、Cochrane Library、Embase,纳入有关围生期感染对新生儿脑损伤影响的研究。文献检索日期截至2020年10月9日。采用固定(随机)效应模型对各个文献报告的研究结果进行合并,并计算比值比(OR值)及相应95%的可信区间(CI)。查找异质性原因及分析潜在的发表偏倚。结果共纳入文献14篇,均为病例对照研究。Meta分析得出的结果示,宫内感染组OR值为4.13[95%CI:3.18~5.37],母亲妊娠期感染性疾病组OR值为9.15[95%CI:5.42~15.45],新生儿感染组OR值为3.04[95%CI:2.24~4.11]。结论发生新生儿脑损伤时,合并感染的风险较高,即新生儿脑损伤与围生期感染有关。

Objective To evaluate the correlation between neonatal brain damage and perinatal infection with Meta-analysis system,identify the cause of brain damage,intervene and treat newborns with brain damage to earliest convenience,and improve the prognosis of newborns.Methods The searched databases involving China Biology Medicine disc(CBM disc),CNKI,VIP,Wanfang,PubMed,Web of Science,Cochrane Library and Embase were included,and the studies on effects of Perinatal infection on neonatal brain damage were included.The literature search was up to October 9,2020.A fixed(random)effect model was utilized to combine findings of literatures,and then the odds ratio(OR value)and corresponding 95%confidence interval(CI)were calculated.The reasons for heterogeneity was sought,and potential publication bias was analyzed.Results A total of 14 articles are included,and all the articles are case-control studies.The results concluded from Meta-analysis show that the OR value of the gestational infectious group was 4.13[95%CI:3.18-5.37],OR value of maternal gestational infectious disease group was 9.15[95%CI:5.42-15.45],and OR value of the neonatal infection group is 3.04[95%CI:2.24-4.11].Conclusion The risk of co-infection is significant when neonatal brain damage occurs,or the neonatal brain damage is related to perinatal infection.