靶向基因编辑系统编辑趋化性细胞因子受体5对HIV感染人体影响的研究进展

Research progress in the effect of targeted gene editing system to edit CCR5 on human infected with HIV

趋化性细胞因子受体5(chemotactic cytokine receptor 5, CCR5)是艾滋病病毒感染人体的主要辅助受体之一。CCR5作为目前抗HIV-1病毒感染的首选靶点,主要基于的原理是通过降低或敲除靶细胞表面CCR5的表达量,进而阻断CCR5与gp120之间的相互作用阻断病毒的感染。CCR5Δ32造血干细胞移植成功治愈HIV感染后,引起了学术界的轰动。CCR5Δ32是一种先天性CCR5基因的32个碱基缺失的突变。由于CCR5Δ32自然突变的概率低,研究人员一直在探索通过靶向基因编辑系统来构建CCR5Δ32的方法。靶向基因编辑系统是近年来以CCR5为靶点预防和治疗艾滋病的重要方法。本文总结了近年来国内外靶向基因编辑技术在编辑CCR5对HIV治疗的研究进展。

Chemotactic cytokine receptor 5(CCR5) is one of the main auxiliary receptors in HIV-infected humans. CCR5,as the current preferred target against HIV-1 virus infection, is mainly based on the principle of blocking viral infection by reducing or knocking out the expression of CCR5 on the surface of the target cell, thereby blocking the interaction between CCR5 and gp120. After the successful cure of HIV infection by CCR5Δ32 hematopoietic stem cell transplantation, it caused a sensation in the academic community. CCR5Δ32 is a congenital mutation in the deletion of 32 bases in the CCR5 gene. Due to the low probability of natural mutations in CCR5Δ32, researchers have been exploring ways to construct CCR5Δ32 by targeting gene editing systems. Targeted gene editing systems are an important method for the prevention and treatment of AIDS with CCR5 as the target in recent years. This paper summarizes the research progress of targeted gene editing technology in editing CCR5 for HIV treatment at home and abroad in recent years.