摘要
马尔堡病毒(Marburg virus,MARV)属丝状病毒科,是已知导致人类严重疾病的烈性的病原体之一,可导致人群大范围流行。2021年8月11日,世界卫生组织宣布西非国家几内亚出现1例马尔堡病毒病死亡病例,为该病毒的防控敲响了警钟。针对马尔堡病毒尚无特效药物和疫苗,相关研究亟待开展,尤其是快速准确的诊断试剂。中国尚无马尔堡病毒病的报道,但存在输入或赴非洲务工而感染的潜在风险,需强化马尔堡病毒病防控意识。本文就马尔堡病毒的病毒学特点、感染特性以及诊断方法进行综述,以增强对马尔堡病毒的认识。
Marburg virus, a member of the Filoviridae family, is the most virulent pathogen known to cause human infection, with a potential to cause a wide range of epidemics. On August 11th, 2021, the World Health Organization(WHO)announced a death case of Marburg virus disease in Guinea, sounding the alarm for the prevention and control of the virus.There are no specific drugs and vaccines for Marburg virus, and relevant researches are urgently needed, especially rapid and accurate diagnostic reagents. There is no report of Marburg virus disease in China, but there is a potential risk of infection caused by imported cases. It is necessary to strengthen the awareness of prevention and control of Marburg virus disease among those who work and travel to Africa. This article reviews the virological characteristics, infection characteristics and diagnostic methods of Marburg virus in order to enhance the cognition of Marburg virus disease.
作者
刘铁柱
李建东
LIU Tie-zhu;LI Jian-dong(National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,NHC Key Laboratory of biosafety,Key Laboratory of Medical Viruses and Viral Diseases,Beijing 100206,China)
出处
《中国热带医学》
CAS
2022年第5期483-488,共6页
China Tropical Medicine
基金
重大传染病防治专项(No.ZDZX-2016ZX10004222-002-LJD(B)-GH)。
关键词
马尔堡病毒
病原学
诊断方法
Marburg virus
etiology
diagnostic methods
