脑胶质瘤微环境中非肿瘤细胞的作用研究进展

Latest Research Findings on the Role of Non-Tumor Cells in Glioma Microenvironment

胶质母细胞瘤治疗效果不佳,以肿瘤细胞为中心的治疗策略难以遏制胶质母细胞瘤的恶性进展。除肿瘤细胞之外,胶质瘤微环境中存在大量非肿瘤细胞以及可溶性细胞因子。非肿瘤细胞包括内皮细胞、周细胞、小胶质细胞/巨噬细胞、间充质细胞、星形胶质细胞、神经元等;上述非肿瘤细胞成分与胶质瘤细胞形成一个有机体并调控胶质瘤的恶性进展。胶质瘤微环境的研究已取得一定进展,有助于开发全新的以非肿瘤细胞为靶点的治疗方法并改善胶质瘤患者预后。本文总结了研究较为广泛的内皮细胞、周细胞、小胶质细胞/巨噬细胞、星形胶质细胞、神经元和间充质细胞与胶质瘤细胞之间的关系以及相应的转化研究,展望了未来基于肿瘤微环境治疗胶质瘤的挑战与机遇。

As the tumor cell-centered treatment strategies cannot curb the malignant progression of glioblastoma effectively,the therapeutic effect of glioblastoma is still not satisfactory.In addition to glioma cells,glioma microenvironment(GME)comprises massive numbers of non-tumor cells and soluble cytokines.The non-tumor cells include endothelial cells,pericytes,microglia/macrophages,mesenchymal cells,astrocytes,neurons,etc.These non-tumor cell components,together with glioma cells,form one organism which regulates the progression of glioma.Considerable progress has been been in research on GME,which will be conducive to the development of non-tumor cell targeted therapies and and improvements in the prognosis of glioma patients.Herein,we summarized the interaction of glioma cells with endothelial cells,pericytes,microglia/macrophages,astrocytes,neurons and mesenchymal cells,a topic that has been extensively researched,as well as the corresponding translational studies.We also discussed the potential challenges and opportunities of developing glioma treatments based on tumor microenvironment.