糖尿病与关节置换术后假体周围感染相关性的系统评价

Correlation between diabetes mellitus and periprosthetic joint infection following total joint arthroplasty:a systematic review

目的系统评价糖尿病(DM)与关节置换术(TJA)后假体周围感染(PJI)的相关性。方法计算机检索PubMed、EMbase和The Cochrane Library数据库,搜集有关DM与TJA后PJI相关性的研究,检索时限均为建库至2021年9月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 13.0软件进行Meta分析。结果共纳入26个研究,包括1750118例患者。Meta分析结果显示,DM患者TJA术后发生PJI的风险明显高于非DM患者[OR=1.42,95%CI(1.32,1.52),P<0.0001]。结论当前证据显示,DM患者比非DM患者TJA术后发生PJI的风险更大。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

Objective To systematically review the correlation of diabetes mellitus(DM)with periprosthetic joint infection(PJI)after total joint arthroplasty(TJA).Methods Studies related to DM with PJI after TJA were collected from PubMed,EMbase and The Cochrane Library from inception to September 2021.Two reviewers independently screened the literature,extracted data and assessed the risk of bias of the included studies.Meta-analysis was then performed using Stata 13.0 software.Results A total of 26 studies involving 1750118 patients were included.The results of meta-analysis showed that the risk of PJI after TJA in DM patients was significantly higher than that in non-DM patients(OR=1.42,95%CI 1.32 to 1.52,P<0.0001).Conclusion Current evidence indicates a higher risk of PJI for DM patients than nonDM patients after TJA.Due to the limited quality and quantity of the included studies,more high-quality studies are required to verify the above conclusion.