儿童癫痫发病危险因素的Meta分析

Meta-analysis of risk factors for epilepsy in children

目的通过系统回顾并分析儿童癫痫发生的危险因素,探讨儿童癫痫发病的相关病因,为防治儿童癫痫发病的危险因素提供循证策略。方法通过在PubMed、Embase、VIP、CNKI、Web of science、Cohrane、CBM上搜索建库至今有关儿童癫痫发病危险因素的研究,选取研究类型为病例对照研究的文献,通过两位评议员对文献进行筛选和质量评价,最终选取符合要求的文献纳入研究,并通过Rev Man5.3软件对提取的目标数据进行统计分析。结果共纳入9篇文献进行儿童癫痫发病危险因素的Meta分析,研究对象共计3792例,其中对照组1922例,病例组1870例。Meta分析结果提示:不良围产期、癫痫家族史、高热惊厥、中枢神经系统感染与儿童癫痫发生密切相关,其OR值分别为[OR=3.46,95%CI(2.51,4.79)]、[OR=4.77,95%CI(3.83,5.95)]、[OR=7.81,95%CI(5.64,10.80)]、[OR=3.00,95%CI(1.44,6.26)],P均<0.05。结论不良围产期、癫痫家族史、高热惊厥、中枢神经系统感染是目前儿童癫痫发病的危险因素。

Objective To systematically review and analyze the risk factors of epilepsy in children,to explore the related etiology of epilepsy in children,and to provide evidence-based strategies for reducing the occurrence of epilepsy in children.Methods PubMed,Embase,VIP,CNKI,Web of science,Cohrane,and CBM were searched for relevant studies on risk factors for childhood epilepsy since the establishment of the database,and the study type was selected as a casecontrol study.After screening and quality evaluation,the literatures that met the requirements were finally selected for inclusion in the study,and the extracted target data were statistically analyzed by RevMan5.3 software.Results A total of 9 literatures were included for Meta-analysis of the risk factors of epilepsy in children.A total of 3792 cases were studied,including 1922 cases in the control group and 1870 cases in the case group.Meta-analysis results showed that adverse perinatal period,family history of epilepsy,febrile seizures,and central nervous system infection were closely related to the occurrence of epilepsy in children,and the OR values were OR=3.46,95%CI(2.51,4.79),OR=4.77,95%CI(3.83,5.95),OR=7.81,95%CI(5.64,10.80),OR=3.00,95%CI(1.44,6.26),P values were all less than 0.05.Conclusions Adverse perinatal period,family history of epilepsy,febrile seizures,and central nervous system infection are the current risk factors for childhood epilepsy.