芪红汤联合美托洛尔治疗冠状动脉粥样硬化性心脏病合并慢性心力衰竭的疗效及对左心室收缩末期内径、左心室舒张末期内径水平的影响

Clinical efficacy of the Qihong decoction plus metoprolol on coronary heart disease with chronic heart failure and its influences on the levels of left ventricular end-systolic diameter and left ventricular end-diastolic diameter

目的:探索芪红汤联合美托洛尔治疗冠状动脉粥样硬化性心脏病(简称冠心病)合并慢性心力衰竭的疗效及对左心室收缩末期内径(Left Ventricular End-Systolic Diameter,LVESD)、左心室舒张末期内径(Left Ventricular End-Diastolic Diameter,LVEDD)水平的影响。方法:选取江南大学附属医院2018年5月-2020年5月收治的冠心病合并慢性心力衰竭的患者96例作为研究对象,随机分为观察组和对照组各48例,对照组予美托洛尔治疗,观察组予芪红汤联合美托洛尔治疗。两组均在治疗1个月后对临床疗效、超声心动指标及血浆N末端B型利钠肽前体(N-terminal Probrain Natriuretic Peptide,NT-proBNP)、超敏C反应蛋白(High-sensitivity C-reactive Protein,hs-CRP)水平进行比较。结果:观察组患者的临床治疗总有效率显著高于对照组;治疗后观察组患者的LVEDD、LVESD显著低于对照组(P <0.05),左心室射血分数(Left Ventricular Ejection Fractions,LVEF)显著高于对照组(P <0.05),血浆NT-proBNP、hs-CRP水平均显著低于对照组(P <0.05)。结论:芪红汤联合美托洛尔治疗冠心病合并慢性心力衰竭疗效显著,且可显著降低患者的LVEDD、LVESD,改善患者心功能。

Objective:To explore clinical efficacy of the Qihong decoction(芪红汤)plus metoprolol on coronary heart disease with chronic heart failure and its influences on LVESD and LVEDD levels.Methods:A total of 96 cases from May 2018 to May 2020 were selected as the research objects,and were randomly divided into the observation group and the control group,and 48 cases in each.The control group was given metoprolol.The observation group were treated with the Qihong decoction plus metoprolol.Results:The total efficiency in the observation group was significantly higher than the control group.After treatment,the LVEDD and LVESD levels in the observation group were significantly lower than those in the control group(P<0.05),and the LVEF level in the observation group was significantly higher than the control group(P<0.05).The levels of plasma NT-proBNP and hs-CRP in the observation group were significantly lower than the control group(P<0.05).Conclusion:The Qihong decoction plus metoprolol shows significant effects on coronary heart disease with chronic heart failure,can significantly reduce the LVEDD and LVESD levels of patients,and improve the cardiac function of patients.