加味茵陈蒿汤对慢性持续期支气管哮喘疗效及炎症因子的影响

The effects of the Yinchenhao decoction on chronic persistent bronchial asthma and its influences on inflammatory factors

目的:探讨加味茵陈蒿汤对慢性持续期支气管哮喘疗效及炎症因子的影响。方法:选取2018年7月-2020年10月洪湖市中医医院收治的湿热型慢性持续期支气管哮喘患者80例为研究对象,应用随机数字表法将患者分为对照组(40例)和观察组(40例),对照组予以布地奈德福莫特罗粉吸入剂雾化吸入治疗,观察组在对照组的基础上加用加味茵陈蒿汤。比较两组治疗总有效率,以及治疗前后中医证候评分、炎症因子[肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、嗜酸粒细胞(Eosinophils,EOS)],并观察不良反应。结果:观察组的治疗总有效率高于对照组,差异有统计学意义(P <0.05)。治疗后,观察组各项中医证候(咳嗽、喘息、咯痰)评分均低于对照组,血清TNF-α、IL-6、EOS水平也低于对照组,差异均有统计学意义(P <0.05)。两组不良反应发生率的差异无统计学意义(P> 0.05)。结论:加味茵陈蒿汤治疗性持续期支气管哮喘疗效确切,能够有效缓解患者临床症状,减轻炎症反应,且安全性良好。

Objective:To investigate the effects of the Yinchenhao decoction(茵陈蒿汤)on chronic persistent bronchial asthma and its influence on inflammatory factors.Methods:A total of 80 cases from July 2018 to October 2020 were selected as the research objects,and were divided into the control group(40 cases)and the observation group(40 cases)by random number table method.The control group was given budesonide formoterol powder atomizated inhalation therapy,and the observation group was given additionally the Yinchenhao decoction.Results:The total efficiency in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of various TCM syndromes(cough,wheezing,and expectoration)in the observation group were lower than those in the control group,and the levels of serum TNF-α,IL-6,and EOS in the observation group were also lower than the control group,and the differences were all statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The Yinchenhao decoction shows definite curative effects on persistent bronchial asthma,can effectively relieve the clinical symptoms and reduce the inflammatory reaction,and has good safety.