不同抗菌药物预防闭合性骨折围手术期感染最小成本分析

Analysis of the Minimum Cost of Different Antibacterial Drugs to Prevent Perioperative Infection of Closed Fractures

目的关于不同抗菌药物在预防闭合性骨折患者围手术期感染中的最小成本分析。方法将2019年1月至2020年1月来我院进行手术治疗的66例闭合性骨折患者按照随机方法分为观察组和对照组,每组33例。分别对两组患者应用头孢唑林和头孢曲松进行抗感染治疗,对两组患者的用药不良反应、用药后的机体状况、用药前后的焦虑和抑郁心理、用药前后的生活质量、患者对药物的满意度和成本情况进行统计和比较。结果观察组(3例,占比为9.09%)患者感染、恶心呕吐、头晕头痛等相关用药不良反应的发生率比对照组(6例,占比为18.18%)明显更低,但差异无统计学意义(P>0.05)。观察组用药后的体温、白细胞计数、中性粒细胞、降钙素原(PCT)表现比对照组明显更好,差异有统计学意义(P<0.05)。用药前,两组患者的焦虑和抑郁情绪比较严重,组间差异无统计学意义(P>0.05);用药后,两组患者的焦虑和抑郁情绪均得到改善,但差异无统计学意义(P>0.05)。两组患者用药前生活质量比较,差异无统计学意义(P>0.05);用药后,两组患者的生活质量都有所提升,且观察组相对更好,差异有统计学意义(P<0.05)。观察组的用药成本明显比对照组更低,差异有统计学意义(P<0.05)。观察组(32例,占比为96.97%)患者对用药的满意度明显比对照组(24例,占比为72.73%)更高,差异有统计学意义(P<0.05)。结论在围手术期为闭合性骨折患者进行抗感染治疗时用药头孢唑林和头孢曲松都能发挥良好的抗感染效果,且不会产生严重的不良反应,能满足患者的心理需求,但头孢唑林用药后患者的生活质量更好,药物成本更低,满意度更高,可更好的兼顾患者的经济效益。

Objective To analyze the minimum cost analysis of the perioperative infection of patients with different antibacterial drugs in preventing closed-closed fractures.Methods Sixty-six patients with closed fractures who came to our hospital from January 2019 to January 2020were divided into observation group and control group according to the random method,with an average of 33 patients per group.Anti-infection therapy for two groups of patients can be used to apply ceptoprazolin and ceptopus pine,respectively,adverse reactions to the two groups of patients,the body condition after medication,anxiety and depression before and after medication,the quality of life before and after medication,the patient’s medicine against the medicine against the medicine satisfaction and cost statistics were compared.Results The observation group(3 cases,accounted for 9.09%)patients infected,nausea,vomiting,dizziness and headache and other related medications,the difference was not statistically significant(P>0.05).The body temperature,white blood cell count,neutral granulocytes,and PCT performance of the observation group are significantly better than the control group,and the differences were statistically significant(P<0.05).Before the medication,the anxiety and depression of the two groups of patients are serious,and the differences between each other are not significant(P>0.05).After the medication,the anxiety and depression of the two groups have been improved,but the differences were still not significant(P>0.05).The quality of life before medication in the two groups was not significantly different(P>0.05).After the medication,the quality of life of the two groups has improved,but the observation group was relatively better(P<0.05).The cost of medication in the observation group is obviously lower than the control group,and the difference was statistically significant(P<0.05).The patients in the observation group(32 cases,accounting for 96.97%)had significantly higher satisfaction with medication than the control group(24 cases,accounting for 72.73%),and the difference was statistically significant(P<0.05).Conclusion The treatment of patients with closed fracture patients while surgical treatment can perform good anti-infection effects during the perioperative surgery during the perioperative surgery.It meets the psychological needs of patients,but after medication for patients,patients have better quality of life,lower drug costs,and higher satisfaction.They can better take into account the patient’s economic benefits.