雷公藤多苷联合醋酸泼尼松治疗肾病综合征患者的效果

Tripterygium Wilfordii Glycoside Combined with Prednisone Acetate in the Treatment of Nephrotic Syndrome

目的评价采取雷公藤多苷与醋酸泼尼松联合治疗肾病综合征患者的可行性,为肾病综合征临床治疗工作提供参考。方法选择我院2018年1月至2019年2月收治的肾病综合征患者,总计70例。结合治疗方法采取随机法分为对照组与观察组,各35例。对照组采取醋酸泼尼松治疗,观察组采取醋酸泼尼松+雷公藤多苷治疗。对比两组患者的治疗情况,包括临床疗效、不良反应以及中医证候积分、24 h尿蛋白定量(24 h Upro)、白蛋白(ALB)、炎性因子水平改善情况。结果治疗前,两组患者中医证候积分、24hUpro、ALB比较接近,P>0.05。治疗后,两组患者中医证候积分、24hUpro、ALB指标较治疗前均有改善,且观察组患者中医证候积分、24 h Upro水平低于对照组,ALB水平高于对照组,P<0.05。观察组患者治疗后临床总有效率高于对照组,P<0.05;观察组不良反应发生率为5.71%,对照组为8.57%,P>0.05;在炎性因子方面,观察组超敏C反应蛋白(hs-CRP)水平低于对照组,P<0.05。结论对比单纯合醋酸泼尼松治疗肾病综合征,在联合雷公藤多苷的基础上可在保障患者用药安全性的同时进一步提高患者的预后效果,促进患者症状体征、24 h Upro、ALB、炎性因子水平的改善。

Objective To evaluate the feasibility of combining tripterygium glycosides and prednisone acetate in the treatment of nephrotic syndrome,so as to provide references for clinical treatment of nephrotic syndrome.Methods A total of 70 patients with nephrotic syndrome who were admitted to our hospital from January 2018 to February 2019 were selected.Combined with the treatment methods of patients with nephrotic syndrome,the patients were randomly divided into two groups,the control group and the observation group,with 35 cases in each group.The control group was treated with prednisone acetate,and the observation group was treated with prednisone acetate+tripterygium glycoside.Compare the treatment of patients with nephrotic syndrome in the control group and the observation group,including the clinical efficacy,adverse reactions,and TCM syndrome integration between the groups,24-hour urine protein quantification(24 h Upro),albumin(ALB),the level of inflammatory factors improved.Results Before treatment,the scores of TCM syndromes,24 h Upro and ALB between the two groups of patients with nephrotic syndrome were relatively close,P>0.05.After treatment,the indicators of the two groups before treatment were improved,and the TCM syndrome score and 24 h Upro level of the observation group were lower than those of the control group,and the ALB level was higher than that of the control group,P<0.05.The total clinical effective rate of the observation group after treatment was higher than the control group,P<0.05;the adverse reactions between the groups were compared,the adverse reactions between the observation group and the control group of nephrotic syndrome patients(5.71%vs.8.57%)were similar,P>0.05.In terms of inflammatory factors,the level of hypersensitive C-reactive protein(hs-CRP)in the observation group was lower than that in the control group,P<0.05.Conclusion Compared with the treatment of nephrotic syndrome with prednisone acetate alone,the combination of tripterygium wilfordii polyglycosides can further improve the prognosis of the patient’s treatment while ensuring the safety of the patient’s medication,and promote the patient’s symptoms and signs,24 h Upro,ALB,and improve inflammation factor level.