微生态制剂双歧杆菌三联活菌散综合治疗新生儿黄疸的临床疗效

Clinical effect of probiotic Bifidobacterium triple viable bacteria powder in the treatment of neonatal jaundice

目的 探讨微生态制剂双歧杆菌三联活菌散综合治疗新生儿黄疸的临床疗效.方法 随机选取2020年10月-2021年10月期间60例黄疸新生儿,按照随机数字表法将这些患儿分成观察组和对照组,每组均30例,对照组使用蓝光等常规治疗;观察组在以上基础上使用双歧杆菌三联活菌散治疗.治疗前后分别采集两组患儿血液以检测血清总胆红素(total serum bilirubin,TSB)水平;记录两组患儿黄疸消退时间和住院时间.比较两组临床治疗效果和不良反应.结果 两组患儿治疗后TSB平均水平较治疗前明显降低,观察组患儿治疗后TSB水平平均为(68.36±2.25)umol/L,低于对照组平均水平(107.85±6.23)umol/L,P<0.05.观察组患儿黄疸消退平均时间和平均住院时间均短于对照组,P<0.05.观察组治疗显效率为83.33%,高于对照组的治疗显效率60.0%,P<0.05.两组治疗期间未见严重不良反应.结论 微生态制剂双歧杆菌三联活菌散综合治疗新生儿黄疸患儿疗效显著且不会增加不良反应,具有推广价值.

0bjective To invesigate the clinical effect of probiotic Bifidobacterium triple viable bacteria powder in the treatment of neonatal jaundice Methods A total of 60 neconates with jaundice from October 2020 to October 2021 were randomly selected and divided into an observation group and a control group according to the random number table method,with 30 cases in each group.The control group received conventional treatment methods such as blue light et al;the observation group was treated with probiotic Bifidobacterium triple viable bacteria powder on the basis of the above.Before and after treatment,blood was collected from the two groups of children to detect total serum bilirubin(TSB) levels;jaundice subsided time and hoepital stay were recorded in two groupe.The clinical therapeutic effects and adverse reactions were compared bewveen the two groups.Results The average level of TSB in the two groups after treatment was significatnly lower than that before treatment.The average level of TSB in the observation group after treatment was(68.36±2.25)umol/L,which was lower than the avenage level in the control group(107.85±6.23)umol/L,P<0.05.The mean time of joundice subsidence and the mean hospital stay of children in the observation group were shorter than those in the control group,P<0.05.The effective rate of the obsevation group was 83.33% higher than that of the conlrol goup,which was 60.0%,P<0.05.No serious advese reactions were observed in the two groups during treatment.Conclusion Probiotic preparation Bifidobacterium triple viable bacteria powder has a significant curative effect in the comprehensive treatment of neonatal jaundice children without inereasing side effects,and has promotion value.