甘草酸单铵半胱氨酸氯化钠注射液预防乳腺癌化疗所致药物性肝损伤的临床研究

Clinical study of Compound glycyrrhizin cysteine sodium chloride in preventing drug-induced liver injury caused by chemotherapy for breast cancer

目的探讨甘草酸单铵半胱氨酸氯化钠注射液预防乳腺癌化疗所致药物性肝损伤的效果.方法60例乳腺癌患者,随机分为实验组(30例)和对照组(30例),对照组仅给予抗肿瘤常规化疗,实验组为甘草酸单铵半胱氨酸氯化钠注射液联合抗肿瘤常规化疗,观察和评估两组患者的肝损伤情况,包括肝损伤发生率、严重程度以及安全性.结果两组的肝损伤发生率和肝损伤严重程度差异有统计学意义(P<0.05),实验组的肝损伤发生率低且严重程度相对较轻,不良反应发生率差异无统计学意义(P>0.05).结论甘草酸单铵半胱氨酸氯化钠注射液对于预防乳腺癌化疗所致药物性肝损伤有效.

0bjective To investigate the efecet of Compound glyeyrhizin cysteine sodium chloride on preventing drug-induced liver injury caused by chemotherapy for breast cancer.Methods 60 patients with breast cancer were randomly divided into observation group(30 cases)and control group(30 cases).The control group only received antitumor conventional chemotherapy,while the experimental group was treated with Compound glyeyrrhizin cysteine sodium chloride combined with anti-tumor conventional chemotherapy.The liver injury of two groups was observed and evaluated,including the incidence and severity of liver injury,and safety.Results There was significant dfference in the incidence and severity of liver injury between the two groups(P<0.05).The incidence of liver injury in the experimental group was lower and the severity was relatively light,and there was no signifcant difference in the incidence of adverse drug reactions(P>0.05).Conclusion Compound glyeyrrhizin cysteine sodium chloride is efective in preventing drug-induced liver injury caused by chemotherapy for breast cancer.