D614G突变对新型冠状病毒致病性、免疫原性的影响

Effects of D614G mutation on pathogenicity and immunogenicity of SARS-CoV-2

新型冠状病毒(SARS-CoV-2)D614G突变体的棘突蛋白中614位氨基酸的天冬酰胺(D)被甘氨酸(G)取代,这在目前流行的病毒株中已占优势。该文综述2021年以来所发表的与D614G突变密切相关文献,内容涉及D614G突变对棘突蛋白结构的影响,D614G突变对新冠病毒致病性的影响,D614G突变与新冠病毒免疫原性及其疫苗的关系,D614G突变在一些国家新冠病毒中的情况,含D614G突变体新冠病毒的诊断与治疗等,以及对这些研究结果的初步分析。将有助于对含D614G突变新型冠状病毒疫情的深入了解与防控。

The 614 amino acid asparagine(D)in New Coronavirus(SARS-CoV-2)spike protein with D614G mutant is replaced by glycine(G),which is dominant in the current virus strains.It is reviewed about the papers closely involved in D614G mutation published in 2021,including the influence of D614G mutation on spike protein structure,effects of D614G mutation on pathogenicity of SARS-CoV-2,relationship between D614G mutation and immunogenicity and vaccine of SARS-CoV-2,the situation of D614G mutation in SARS-CoV-2 of some countries,the diagnosis and treatment of SARS-CoV-2 containing D614G mutant,and the preliminary analysis of these research results.It is helpful to understand and prevent the epidemic of SARS-CoV-2 with D614G mutation.