鲍曼不动杆菌血流感染患者的临床特征及其死亡的危险因素

Clinical characteristics of Acinetobacter baumannii bloodstream infection and its risk factors for mortality

目的分析鲍曼不动杆菌血流感染患者的临床特征及其死亡的危险因素。方法根据28 d内是否死亡,鲍曼不动杆菌血流感染患者122例分为死亡组(61例)和生存组(61例),比较两组临床特征,分析鲍曼不动杆菌血流感染死亡的危险因素。结果两组临床指标和实验室指标均有统计学差异(P<0.05)。死亡组肺部感染来源的比例高于生存组(50.8%vs.31.1%)(P<0.05)。死亡组鲍曼不动杆菌对目标抗生素的耐药率高于生存组(34.4%vs.18.0%)(P<0.05)。序贯器官衰竭估计(SOFA)评分>6分、脓毒性休克和多重耐药是鲍曼不动杆菌血流感染死亡的独立危险因素(P<0.05)。结论SOFA评分>6分、脓毒性休克和多重耐药是鲍曼不动杆菌血流感染的独立危险因素,提示患者预后差。

Objectives To analyze the clinical characteristics of Acinetobacter baumannii bloodstream infection and its risk factors for mortality.Methods According to whether they died within 28 days,122 patients with Acinetobacter baumannii bloodstream infection were divided into two groups of A(death,61 cases)and B(survival,61 cases).The clinical characteristics of two groups were compared,and the risk factors for mortality were analyzed.Results There were significant differences in clinical and biological indicators between the two groups(P<0.05).The proportion of sources of pulmonary infection in group A was higher than that in group B(50.8%vs.31.1%)(P<0.05).The resistance rate of Acinetobacter baumannii to target antibiotics in group A was higher than that in group B(34.4%vs.18.0%)(P<0.05).Sequential organ failure assessment(SOFA)score>6 points,septic shock and multi-drug resistance were the independent risk factors for mortality in the patients with Acinetobacter baumannii bloodstream infection(P<0.05).Conclusion SOFA score>6 points,septic shock and multi-drug resistance are the independent risk factors for mortality in the patients with Acinetobacter baumannii bloodstream infection.