针刺联合中药内服治疗糖尿病视网膜病变效果的Meta分析

Effect of Acupuncture Combined with Traditional Chinese Medicine in Treatment of Diabetic Retinopathy:A Meta-Analysis

目的:应用Meta分析针刺联合中药内服治疗糖尿病视网膜病变(diabetic retinopathy,DR)的临床疗效。方法:检索PubMed、 Embase、Web of Science、Cochrane Library、中国知网(CNKI)期刊数据库、万方数据库及中国生物医学文献数据库(SinoMed)中针刺联合疗法治疗DR的文献,运用Stata进行Meta分析。结果:共纳入10篇文献,Meta分析结果显示,与其他治疗疗法相比,针刺联合中药内服显著提高了总有效率(RR=1.21,95%CI为1.13~1.30)、视力水平(WMD=0.18,95%CI为0.11~0.25)、黄斑厚度(WMD=-32.25,95%CI为-48.94~-15.56)和视敏度(WMD=2.92,95%CI为2.57~3.27),与对照组相比差异均有统计学意义(P<0.01)。结论:针刺联合中药内服用于治疗DR可以显著提高患者视力水平和视敏度,降低黄斑厚度,减缓疾病发展,改善患者症状。

Objective:Meta-analysis was conducted to investigate the effect of acupuncture combined with Traditional Chinese medicine(TCM) in the treatment of diabetic retinopathy(DR). Methods:Studies on the effect of combination treatment in DR in PubMed,Embase,Web of Science,Cochrane Library,CNKI,WanFang and SinoMed database were systematically reviewed and included.The data analysis was performed using Stata software. Results:A total of 10 studies were included. Compared with other treatment,the combination treatment significantly improved the overall effective rate(RR=1.21,95%CI between 1.13 to 1.30),visual acuity level(WMD=0.18,95%CI between 0.11 to 0.25),macular thickness(WMD=-32.25,95%CI between-48.94 to-15.56),and visual acuity(WMD=2.92,95%CI between 2.57 to 3.27). Compared with the control group,the difference was statistically significant(P<0.01). Conclusion:Acupuncture combined with Chinese Herb in the treatment of DR can improve the visual acuity and visual acuity,reduce the thickness of the macula,which slows down disease progression and improve the symptoms of patients.