柴胡加龙骨牡蛎汤治疗永久性房颤伴失眠患者的效果

Effects of Chaihu Longgu Oyster soup in treatment of patients with permanent atrial fibrillation and insomnia

目的:探讨柴胡加龙骨牡蛎汤治疗永久性房颤伴失眠患者的效果。方法:选取2019年1月至2019年12月该院收治的100例永久性房颤伴失眠患者进行前瞻性研究,以掷骰子法将患者分为对照组和观察组,各50例。两组均口服盐酸胺碘酮片进行抗心律失常治疗,在此基础上,对照组采用艾司唑仑和谷维素治疗,观察组采用柴胡加龙骨牡蛎汤治疗。比较两组治疗前后中医证候积分、匹兹堡睡眠质量指数(PSQI)评分、血清神经递质[多巴胺、5-羟色胺、P物质]水平,以及不良反应发生率。结果:治疗后,观察组中医证候积分、PSQI评分及多巴胺、5-羟色胺水平均低于对照组,P物质水平高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为6.00%(3/50),低于对照组的22.00%(11/50),差异有统计学意义(P<0.05)。结论:柴胡加龙骨牡蛎汤治疗永久性房颤伴失眠患者可改善失眠症状和睡眠质量,降低血清多巴胺、5-羟色胺水平,提高P物质水平,且不良反应少,效果优于艾司唑仑和谷维素治疗。

Objective: To explore effects of Chaihu Longgu Oyster soup in treatment of patients with permanent atrial fibrillation and insomnia.Methods: A total of 100 patients with permanent af and insomnia admitted to our hospital from January 2019 to December 2019 were selected for a prospective study, and the patients were divided into control group and observation group by dice rolling method, with 50 patients in each group. Both groups of patients were treated with oral Amiodarone hydrochloride tablets for antiarrhythmic treatment. On this basis, the control group was treated with Estazolam and Oryzanol,while the observation group was treated with Chaihu Longgu Oyster soup. The TCM syndrome score, the Pittsburgh sleep quality index(PSQI) score, the serum neurotransmitter levels(dopamine, serotonin, substance P) and the occurrence of adverse reactions were compared between the two groups before and after the treatment. Results: After the treatment, the TCM syndrome score, the PSQI score, and the dopamine and serotonin levels in the observation group were lower than those in the control group;the level of substance P was higher than that in the control group;and the differences were statistically significant(P<0.05). Further,the incidence of adverse reactions in the observation group was 6.00%(3/50), which was lower than 22.00%(11/50) in the control group, and the difference was statistically significant(P<0.05). Conclusions: Chaihu Longgu Oyster soup in the treatment of the patients with permanent atrial fibrillation and insomnia can improve the insomnia symptoms and the sleep quality, reduce the serum dopamine and serotonin levels, and increase the serum neurotransmitter levels with fewer adverse reactions. Moreover, it is superior to Estazolam and Oryzanol.