Nucleus accumbens-linked executive control networks mediating reversal learning in tree shrew brain

DEAR EDITOR,Cognitive flexibility is crucial for animal survival but is frequently impaired in neuropsychiatric disorders.Although many brain structures and functional networks are involved in cognitive flexibility,the neural mechanisms underlying cooperation among specific functional networks remain unclear from a global perspective.In this study,[^(18)F]-fluorodeoxyglucose positron emission tomography(FDG-PET)was performed on 19 male tree shrews after four different visual discrimination tasks,including baseline,learning expert(LE),reversal naive(RN),and reversal expert(RE).