B7家族在肿瘤中的表达及临床意义研究进展

The expression and clinical significance of B7 family in tumors

B7家族属于免疫球蛋白超家族,是最先被证实在T细胞活化中起关键作用的共刺激分子,许多研究证实,B7家族在肿瘤中表达异常,且与临床病理特征及不良预后相关。随着对癌症与免疫系统相互作用研究的日益深入,针对B7家族的免疫疗法已成为恶性肿瘤治疗的新选择。本文将对B7家族分子的表达、功能以及临床意义作一综述,旨在探索其在肿瘤治疗中的应用和前景。

B7 family belongs to the immunoglobulin superfamily,which is the first co-stimulatory molecule that is proved to play a key role in T cell activation,many studies have confirmed that B7 family expression is abnormal in tumors,and it is related to clinicopathological characteristics and poor prognosis.With the deepening of the research on the interaction between cancer and immune system,immunotherapy of B7 family has become a new choice for malignant tumor treatment.This article will review the expression,function and clinical significance of B7 family molecules,in order to explore its application and prospect in tumor therapy.