摘要
肠道菌群对人体代谢和肠外器官产生广泛的影响。最近研究表明,肠道菌群失调通过多种途径促进心血管疾病的发生和发展。中枢神经系统调节心血管系统,近年来研究发现由肠道菌群及其代谢产物和中枢神经系统构成的肠-脑轴在高血压、心律失常和心力衰竭等心血管疾病的发生和发展中发挥重要作用。目前,肠-脑轴与心血管疾病的详细机制日渐清晰,现就肠道菌群通过肠-脑轴促进心血管疾病的最新研究机制进行综述。
The gut microbiota has a wide range of effects on human metabolism and extra-intestinal organs.Recent studies have shown that intestinal microbes disturbance promotes the occurrence and development of cardiovascular disease through various pathways.The central nervous system regulates the cardiovascular system.In recent years,it has been found that the gut-brain axis composed of intestinal flora and its metabolites and the central nervous system plays an important role in the occurrence and development of cardiovascular disease such as hypertension,arrhythmia and heart failure.At present,the detailed mechanism of gut-brain axis and cardiovascular disease is becoming increasingly clear.This paper reviews the latest research mechanism of gut microbiota promoting cardiovascular disease through gut-brain axis.
作者
谭伍平
王猛
周晓亚
TAN Wuping;WANG Meng;ZHOU Xiaoya(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute,Hubei Key Laboratory of Cardiology,Cardiac Autonomic Nervous System Research Center of Wuhan University,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2022年第7期595-599,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金面上项目(81970287)。
关键词
肠道菌群
肠-脑轴
自主神经系统
心血管疾病
Gut microbiota
Gut-brain axis
Autonomic nervous system
Cardiovascular disease
