急性心肌梗死后心脏破裂机制的研究进展

Mechanism of Cardiac Rupture After Acute Myocardial Infarction

急性心肌梗死后心脏破裂的具体病理生理机制尚不完全清楚,缺乏明确的预测指标和药物干预靶点。目前研究显示其机制可能与炎症反应过度、基质金属蛋白酶家族表达失衡、肾素-血管紧张素系统激活、细胞的凋亡与自噬、细胞内钙稳态与线粒体稳态、血小板活化和冠状动脉微循环障碍等因素相关。现就此做一综述。

The specific pathophysiological mechanism is still unclear about cardiac rupture after acute myocardial infarction.The clinical indicator and related drug intervention target are still unknown.Current studies have shown that its mechanism may be related to excessive inflammatory response,imbalance of matrix metalloproteinase family expression,renin-angiotensin system activation,apoptosis and autophagy,intracellular calcium homeostasis and mitochondrial homeostasis,platelet activation and coronary microcirculation disorder.This is a summary about it.