新活素联合小剂量速尿治疗急性心肌梗死合并心力衰竭的效果分析

Effect analysis of Xinhuosu combined with low-dose Lasix in the treatment of patients with acute myocardial infarction and heart failure

目的 分析冻干重组人脑利钠肽(商品名:新活素)联合小剂量呋塞米(商品名:速尿)治疗急性心肌梗死合并心力衰竭患者的临床效果。方法 100例急性心肌梗死合并心力衰竭患者,采取电脑系统随机排序分组方式分为对照组和观察组,各50例。对照组患者采用小剂量速尿进行治疗,观察组采用新活素联合小剂量速尿进行治疗。对比两组患者临床疗效及治疗前后心功能指标(血清脑利钠肽、左室舒张末期内径、左室射血分数)。结果 观察组治疗总有效率96.00%显著高于对照组的82.00%,差异具有统计学意义(P<0.05)。治疗前,两组患者血清脑利钠肽、左室舒张末期内径、左室射血分数对比,差异无统计学意义(P>0.05);治疗后,观察组患者血清脑利钠肽、左室舒张末期内径、左室射血分数分别为(1925.67±175.46)pg/ml、(38.45±5.47)mm、(51.12±1.01)%,均高于对照组的(3061.52±150.45)pg/ml、(49.52±7.25)mm、(45.56±1.57)%,差异具有统计学意义(P<0.05)。结论 采用新活素联合小剂量速尿治疗急性心肌梗死合并心力衰竭疗效显著,患者的心功能水平明显得到改善,故而具有可推广价值。

Objective To analyze the clinical effect of lyophilized recombinant human brain natriuretic peptide(trade name:Xinhuosu)combined with low-dose furosemide(trade name:Lasix)in the treatment of patients with acute myocardial infarction and heart failure.Methods A total of 100 patients with acute myocardial infarction and heart failure were divided into control group and observation group by computer system,with 50 cases in each group.The control group was treated with low-dose furosemide,and the observation group was treated with Xinhuosu combined with low-dose furosemide.The clinical efficacy and cardiac function indexes(serum brain natriuretic peptide,left ventricular end-diastolic diameter,left ventricular ejection fraction)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.00%,which was significantly higher than 82.00%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in serum brain natriuretic peptide,left ventricular end-diastolic diameter and left ventricular ejection fraction between the two groups(P>0.05).After treatment,the serum brain natriuretic peptide,left ventricular end-diastolic diameter and left ventricular ejection fraction of the observation group were(1925.67±175.46)pg/ml,(38.45±5.47)mm,and(51.12±1.01)%,which were higher than(3061.52±150.45)pg/ml,(49.52±7.25)mm,and(45.56±1.57)%of the control group,and the difference was statistically significant(P<0.05).Conclusion Xinhuosu combined with low-dose furosemide has significant efficacy in the treatment of acute myocardial infarction complicated with heart failure,and it can obviously improve the cardiac function of patients,so it has the value of popularization and application.