对比头孢吡肟、左氧氟沙星对老年支气管肺炎患者的治疗价值

Comparison of the therapeutic value of cefepime and levofloxacin in elderly patients with bronchial pneumonia

目的 对比老年支气管肺炎患者应用头孢吡肟、左氧氟沙星的效果。方法 102例老年支气管肺炎患者,采取随机数字表法分为对照组及观察组,每组51例。对照组应用左氧氟沙星治疗,观察组应用头孢吡肟治疗。比较两组疗效、炎性因子水平、不良反应发生情况、用药至体温恢复时间及抗菌药物治疗费用。结果 观察组患者的总有效率为94.12%,与对照组的90.20%对比,差异无统计学意义(P>0.05)。治疗后,两组患者白细胞介素-6(IL-6)均低于本组治疗前、白细胞介素-10(IL-10)水平均高于本组治疗前,差异具有统计学意义(P<0.05);但两组IL-6、IL-10水平组间对比差异无统计学意义(P>0.05)。观察组患者的用药至体温恢复时间(2.22±0.30)d短于对照组的(4.03±0.36)d,抗菌药物治疗费用(311.30±24.36)元低于对照组的(988.89±43.72)元,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率7.84%低于对照组的23.53%,差异具有统计学意义(P<0.05)。结论 头孢吡肟、左氧氟沙星治疗老年支气管肺炎均能够达到良好的效果,降低炎症因子水平,其中头孢吡肟在退热、价格以及安全性方面具有一定优势。

Objective To compare the effect of cefepime and levofloxacin in elderly patients with bronchial pneumonia.Methods A total of 102 elderly patients with bronchial pneumonia were divided into control group and observation group by random numerical table,with 51 cases in each group.The control group was treated with levofloxacin,and the observation group was treated with cefepime.The clinical efficacy,inflammatory factor levels,occurrence of adverse reactions,time from medication to body temperature recovery and the cost of antibiotic treatment were compared between the two groups.Results The total effective rate in the observation group was 94.12%,which was not statistically significant compared with 90.20%in the control group(P>0.05).After treatment,the levels of interleukin-6(IL-6)in the two groups were lower than those before treatment in this group,and the levels of interleukin-10(IL-10)in the two groups were higher than those before treatment in this group.All the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the levels of IL-6 and IL-10 between the two groups(P>0.05).The time from medication to body temperature recovery(2.22±0.30)d in the observation group was shorter than(4.03±0.36)d in the control group,and the cost of antibiotic treatment(311.30±24.36)yuan was lower than(988.89±43.72)yuan in the control group.All the differences were statistically significant(P<0.05).The incidence of adverse reactions 7.84%in the observation group was lower than 23.53%in the control group,and the difference was statistically significant(P<0.05).Conclusion Both cefepime and levofloxacin can achieve good therapeutic effects in the treatment of elderly patients with bronchial pneumonia,and reduce the level of inflammatory factors,among which cefepime has certain advantages in terms of antipyretic,price and safety.