达格列净联合胰岛素短期强化治疗对新诊断2型糖尿病患者的疗效分析

Efficacy analysis of dapagliflozin combined with short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes mellitus

目的 探究达格列净联合胰岛素短期强化治疗对新诊断2型糖尿病(NDT2DM)患者的临床疗效。方法 100例NDT2DM患者,依据双盲法将其分为对照组与观察组,各50例。对照组采用胰岛素短期强化治疗,观察组采用达格列净联合胰岛素短期强化治疗。比较两组治疗前后血糖指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PBG)、空腹胰岛素(FINS)]及胰岛功能指标[胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]。结果 治疗后,观察组FBG、HbA1c、2 h PBG分别为(5.75±0.64)mmol/L、(6.25±0.49)%、(7.49±1.40)mmol/L,均低于对照组的(7.02±0.75)mmol/L、(7.70±0.57)%、(9.31±1.48)mmol/L,FINS(15.29±3.16)mU/L高于对照组的(10.53±2.44)mU/L,差异均有统计学意义(P<0.05)。治疗后,观察组HOMA-IR(2.77±0.27)低于对照组的(3.35±0.32),HOMA-β(5.71±0.28)高于对照组的(4.56±0.56),差异均有统计学意义(P<0.05)。结论 为NDT2DM患者应用达格列净联合胰岛素短期强化治疗效果显著,值得临床推广应用。

Objective To investigate the clinical efficacy of dapagliflozin combined with short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes mellitus(NDT2DM).Methods A total of 100 patients with NDT2DM were divided into control group and observation group according to double-blind method,with 50 cases in each group.The control group received short-term intensive insulin therapy,while the observation group received dapagliflozin combined with short-term intensive insulin therapy.Both groups were compared in terms of blood glucose indicators[fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),2-h postprandial blood glucose(2 h PBG),fasting insulin(FINS)]and islet function indicators[homeostatic model assessment for insulin resistance(HOMA-IR),homeostatic model assessment-β(HOMA-β)]before and after treatment.Results After treatment,the FBG,HbA1c,and 2 h PBG of the observation group were(5.75±0.64)mmol/L,(6.25±0.49)%,and(7.49±1.40)mmol/L,which were lower than(7.02±0.75)mmol/L,(7.70±0.57)%,and(9.31±1.48)mmol/L of the control group,and the FINS(15.29±3.16)mU/L was higher than(10.53±2.44)mU/L of the control group.All the differences were statistically significant(P<0.05).After treatment,the HOMA-IR(2.77±0.27)of the observation group was lower than(3.35±0.32)of the control group,and the HOMA-β(5.71±5.28)was higher than(4.56±4.56)of the control group,and the differences were statistically significant(P<0.05).Conclusion Dapagliflozin combined with short-term intensive insulin therapy has significant effect on patients with NDT2DM,and it is worthy of clinical promotion and application.