多巴胺受体激动剂治疗小儿多动症的临床疗效

Clinical efficacy of dopamine receptor agonists in children with attention deficit hyperactivity disorder

目的 探讨多巴胺受体激动剂治疗小儿多动症的临床疗效。方法 80例小儿多动症患儿,随机分为观察组和对照组,各40例。对照组患儿给予盐酸哌甲酯控释片(商品名:专注达)治疗,观察组患儿给予多巴胺受体激动剂吡贝地尔缓释片治疗。对比两组患儿治疗效果、行为问题评分、多巴胺水平、多动指数、不良反应发生率。结果 观察组患儿治疗总有效率90.0%明显高于对照组的70.0%,差异有统计学意义(P<0.05)。观察组患儿心理问题、品行问题及学习问题评分分别为(0.78±0.21)、(0.62±0.18)、(0.75±0.26)分,低于对照组的(1.34±0.57)、(1.13±0.39)、(1.33±0.62)分,差异具有统计学意义(P<0.05)。观察组患儿多巴胺水平明显高于对照组,多动指数明显低于对照组,差异有统计学意义(P<0.05)。观察组患儿不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 对多动症患儿采用多巴胺受体激动剂进行治疗具有更好的效果,能够显著改善患儿的行为症状、多动指数等,同时还能够降低患儿不良反应的发生率。

Objective To discuss the clinical efficacy of dopamine receptor agonists in children with attention deficit hyperactivity disorder.Methods A total of 80 children with attention deficit hyperactivity disorder were randomly divided into observation group and control group,with 40 cases in each group.Children in the control group were treated with methylphenidate hydrochloride controlled-release tablets(trade name:Oncerta),and children in the observation group were treated with the dopamine receptor agonist piribedil sustained-release tablets.The therapeutic effect,behavioral problem score,dopamine level,hyperactivity index,and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 90.0%,which was significantly higher than 70.0%in the control group,and the difference was statistically significant(P<0.05).The scores of psychological problems,conduct problems and learning problems in the observation group were(0.78±0.21),(0.62±0.18),and(0.75±0.26)points,which were lower than(1.34±0.57),(1.13±0.39),and(1.33±0.62)points in the control group,and the differences were statistically significant(P<0.05).The level of dopamine in the observation group was significantly higher than that in the control group,and the hyperactivity index was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Dopamine receptor agonists has better therapeutic effect on children with attention deficit hyperactivity disorder,which can significantly improve children's behavioral symptoms,hyperactivity index,while reducing the incidence of adverse reactions in children.