心包内心外膜脂肪百分比与2型糖尿病患者早期心功能相关性的研究

Relationship between pericardium pericardium fat percentage and early car diac function in patients with type 2 diabetes mellitus

目的:探究2型糖尿病患者早期心功能与心包内心外膜脂肪(EAT)百分比的相关性。方法:将近年来常州市第三人民医院门诊接诊的2型糖尿病患者90例纳入糖尿病组,另选取120例于该医院进行体检的健康人纳入对照组。对两组研究对象均进行常规超声心动图检查及冠状动脉CT血管造影(CCTA)检查,比较其EAT体积、心包内EAT百分比、射血分数(EF)、心输出量(CO)、左心室每搏输出量(SV)、心指数(CI)、左室内径缩短率(FS)及其他基础指标(人口学信息和实验室指标),同时比较糖尿病组患者中不同SV患者的上述指标,分析2型糖尿病患者的SV与其各指标间的相关性。结果:糖尿病组患者的收缩压、舒张压、SV均低于对照组健康人,其EAT体积、心包内EAT百分比及空腹血糖、三酰甘油、糖化血红蛋白的水平均高于对照组健康人,P<0.05。在糖尿病组患者中,与低SV组患者相比,高SV组患者中男性的占比更高,其总胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白的水平和心包内EAT百分比均更低,P<0.05。总胆固醇、低密度脂蛋白胆固醇、心包内EAT百分比是影响2型糖尿病患者SV的独立危险因素,这三项指标与SV均呈负相关(r=-0.137、-0.379、-0.502,P均<0.05)。结论:2型糖尿病患者心包内EAT百分比与其早期心功能及SV下降存在相关性,可将心包内EAT百分比作为评估2型糖尿病患者心功能的重要指标。

Objective:To investigate the correlation between early cardiac function and pericardium epicardial fat(EAT)percentage in patients with type 2 diabetes mellitus.Methods:90 patients with type 2 diabetes treated in changzhou Third People’s Hospital in recent years were included in the diabetes group,and another 120 healthy people who underwent physical examination in the hospital were included in the control group.Routine echocardiography and coronary CT angiography(CCTA)were performed for both groups.Comparison,pericardial EAT EAT volume percentage,ejection fraction(EF),cardiac output(CO),left ventricular stroke output(SV),cardiac index(CI),left the interior diameter shortening rate(FS)and other basic indicators(demographic information and laboratory indexes),diabetes patients and in patients in different SV of the indicators,To analyze the correlation between SV and its indexes in type 2 diabetes patients.Results:Systolic blood pressure,diastolic blood pressure and SV in diabetic group were lower than those in healthy control group,while EAT volume,percentage of EAT in pericardium and levels of fasting blood glucose,triglyceride and hba1c were higher than those in healthy control group,P<0.05.In the diabetic group,compared with the low SV group,the proportion of male patients in the high SV group was higher,and the levels of total cholesterol,low density lipoprotein cholesterol,hemoglobin a1c and percentage of pericardial EAT were lower,P<0.05.Total cholesterol,low density lipoprotein cholesterol and pericardial EAT percentage were independent risk factors for SV in type 2 diabetes mellitus,and these three indicators were negatively correlated with SV(r=-0.137,-0.379,-0.502,P<0.05).Conclusions:The percentage of pericardial EAT in patients with type 2 diabetes mellitus is correlated with early cardiac function and SV decline,and the percentage of pericardial EAT can be used as an important indicator to evaluate the cardiac function in patients with type 2 diabetes mellitus.