血浆PCT检测和DIC评分在DIC早期诊断中的应用价值

Application value of plasma PCT detection and DIC score in early diagnosi s of DIC

目的:探讨血浆降钙素原(PCT)检测和弥散性血管内凝血(DIC)评分在DIC早期诊断中的应用价值。方法:将2019年1月至2021年12月期间麻城市人民医院收治的100例存在DIC发病潜在指征(DIC评分≥5分或患有可诱发DIC的潜在疾病)的患者作为试验组,将该医院同期收治的100例DIC评分<5分的患者作为对照组。对两组患者均进行凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板(PLT)计数、血浆D-二聚体(D-D)、血浆纤维蛋白原(FIB)及血浆降钙素原(PCT)检测,并依据PT、APTT、PLT计数、DD、FIB等指标计算其DIC评分。分析并总结PCT检测和DIC评分在早期DIC诊断中的应用价值。结果:试验组中有71例患者发生DIC,其DIC的发生率为71.00%(71/100)。对照组中有2例患者发生DIC,其DIC的发生率为2%(2/100)。在共计200例患者中,DIC患者血浆PCT的水平和DIC评分均高于非DIC患者,且DIC评分≥5分的患者血浆PCT的水平明显高于DIC评分<5分的患者,差异有统计学意义(P<0.05)。血浆PCT的水平与PLT计数呈负相关(r=-0137,P=0.020),与血浆D-D的水平呈正相关(r=0.132,P=0.040),与DIC评分呈显著正相关(r=0.145,P=0.003)。DIC评分越高则患者越易发生凝血,其DIC的发生率也越高。结论:血浆PCT检测和DIC评分在DIC的早期诊断中具有较高的应用价值。

Objective:To investigate the value of plasma calcitoninogen(PCT)assay and disseminated intravascular coagulation(DIC)score in the early diagnosis of DIC.Methods:One hundred patients with potential indications for the development of DIC(DIC score≥5 or suffering from an underlying disease that can trigger DIC)admitted to the People’s Hospital of Massachusetts City between January 2019 and December 2021 were selected as study subjects.Prothrombin time(PT),activated partial thromboplastin time(APTT),platelet count(PLT),plasma D-dimer(D-D),plasma fibrinogen(FIB)and plasma calcitoninogen(PCT)were measured in these patients,and their DIC scores were calculated based on PT,APTT,PLT count,DD,FIB and other indicators.The value of PCT test and DIC score in the diagnosis of early DIC was analysed and summarised.Results:Among 200 patients,100 patients were used as the experimental group(DIC≥5).71 patients in the experimental group had DIC,and their DIC incidence rate was 71.00%(71/100).In the control group,2 patients had DIC,and the incidence of DIC was 2%.In a total of 200 patients,plasma PCT levels and DIC scores were higher in patients with DIC than in those without DIC,and plasma PCT levels were significantly higher in patients with DIC scores≥5 than in those with DIC scores<5,with statistically significant differences(p<0.05).Plasma PCT levels were negatively correlated with PLT count(r=-0137,P=0.020),positively correlated with plasma D-D levels(r=0.132,P=0.040)and significantly correlated with DIC score(r=0.145,P=0.003).the higher the DIC score,the more likely the patients were to clot and the higher the incidence of DIC.Conclusion:The plasma PCT test and DIC score are of high value in the early diagnosis of DIC.