心血管疾病与2型糖尿病周围神经病变的关系

Relationship between cardiovascular disease and type 2 diabetic peripheral neuropathy

目的:分析心血管疾病与2型糖尿病(T2DM)患者糖尿病周围神经病变(DPN)的关系。方法:选取2015年1月至2019年7月河北省三河燕郊福合第一医院收治的216例T2DM患者作为研究对象。统计这些患者DPN的发生率,并对其人口学特征、实验室指标及合并基础疾病的情况进行对比分析,采用多因素Logistic回归分析法分析心血管疾病与DPN的关系。结果:在216例T2DM患者中,有86例患者发生DPN,其DPN的发生率为39.81%。与无DPN患者相比,DPN患者的病程更长,其糖化血红蛋白和血浆低密度脂蛋白胆固醇的水平均更高,其中合并有心血管疾病患者的占比更高,差异有统计学意义(P<0.05)。经多因素logistic回归分析可知,合并有心血管疾病是导致T2DM患者并发DPN的独立危险因素(P=0.002,95%置信区间为1.822~3.165)。结论:合并有心血管疾病的T2DM患者其DPN的发病风险可明显增加。

Objective:To analyze the relationship between cardiovascular disease and diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 216 T2DM patients admitted to Fuhe First Hospital of Sanhe Yanjiao,Hebei Province from January 2015 to July 2019 were selected as the study subjects.The incidence of DPN in these patients was statistically analyzed,and the demographic characteristics,laboratory indicators and combined underlying diseases were compared and analyzed.The relationship between cardiovascular disease and DPN was analyzed by Logistic regression analysis.Results:Among 216 patients with T2DM,there were 86 patients with DPN,and the incidence of DPN was 39.81%.Compared with patients without DPN,DPN patients had a longer course of disease,higher levels of hBA1c and plasma low density lipoprotein cholesterol,and the proportion of patients with cardiovascular disease was higher,the difference was statistically significant(P<0.05).Multivariate logistic regression analysis showed that the presence of cardiovascular disease was an independent risk factor for DPN in T2DM patients(P=0.002,95%confidence interval 1.822 to 3.165).Conclusions:The risk of DPN in T2DM patients with cardiovascular disease is significantly increased.