复方芩兰口服液治疗RSV下呼吸道感染对患者miR-145和Th1/Th2的影响

Effect of Compound Qinlan oral liquid on Mir-145 and Th1/Th2 in patients with LOWER respiratory tract infection of RSV

目的:探究与分析呼吸道合胞病毒(RSV)下呼吸道感染行复方芩兰口服液治疗对微小RNA-145(miR-145)和Th1/Th2细胞因子水平的影响。方法:采用随机数表法将齐齐哈尔医学院附属第三医院自2019年1月-2021年1月收治的116例RSV下呼吸道感染患者分为对照组和观察组(58例/组)。为对照组患者采用布地奈德联合孟鲁斯特进行治疗,在此基础上为观察组患者加用复方芩兰口服液进行治疗,然后对比两组患者的临床疗效、治疗前后的呼吸功能及微小RNA-145(miR-145)和Th1/Th2细胞因子的水平。结果:1)与对照组患者相比,观察组患者治疗的总有效率较高,差异有统计学意义(P<0.05)。2)与治疗前相比,两组患者治疗后的FVC、FEV_(1)及PEF均较高,差异有统计学意义(P<0.05)。与对照组患者相比,观察组患者治疗后的FVC、FEV_(1)及PEF均较高,差异有统计学意义(P<0.05)。3)与治疗前相比,两组患者治疗后miR-145的表达水平均较低,其Th1/Th2细胞因子的水平均较高,差异有统计学意义(P<0.05)。与对照组患者相比,观察组患者治疗后miR-145的表达水平较低,其Th1/Th2细胞因子的水平较高,差异有统计学意义(P<0.05)。结论:用复方芩兰口服液治疗RSV下呼吸道感染的临床疗效显著,可有效改善患者的呼吸功能,调节其miR-145和Th1/Th2细胞因子的水平。

Objective:To explore and analyze the effects of compound Qinlan oral solution on Mir-145(Mir-145)and Th1/Th2 cytokine levels of respiratory syncytial virus(RSV)infection in lower respiratory tract.Methods:A total of 116 patients with LOWER respiratory tract infection of RSV admitted to the Third Affiliated Hospital of Qiqihar Medical College from January 2019 to January 2021 were divided into control group and observation group(58 cases/group)by random number table method.Patients in the control group were treated with budesonide combined with Montelast,and patients in the observation group were treated with Compound Qinlan oral solution on this basis.Then,the clinical efficacy,respiratory function,microrNA-145(Mir-145)and Th1/Th2 cytokine levels of patients in the two groups were compared.Results:1)Compared with the control group,the total effective rate of observation group was higher,and the difference was statistically significant(P<0.05).2)Compared with before treatment,FVC,FEV_(1)and PEF in 2 groups were higher after treatment,and the differences were statistically significant(P<0.05).Compared with control group,FVC,FEV_(1)and PEF in observation group were higher after treatment,the differences were statistically significant(P<0.05).3)Compared with before treatment,the expression level of Mir-145 was lower in both groups after treatment,and the Th1/Th2 cytokine level was higher in both groups,with statistical significance(P<0.05).Compared with the control group,the expression level of Mir-145 was lower and the Th1/Th2 cytokine level was higher in the observation group after treatment,with statistical significance(P<0.05).Conclusion:Compound Qinlan oral liquid has significant clinical efficacy in the treatment of RSV lower respiratory tract infection,which can effectively improve the respiratory function of patients and regulate the levels of Mir-145 and Th1/Th2 cytokines.