磷酸酯键基智能响应体系在生物医学领域的研究进展

Progress in Research of Phosphate Ester Bond Based Intelligent Response System for Biomedical Fields

磷酸酯键是人体内参与核酸和细胞膜合成的化学键,由磷酸或磷酰氯与醇羟基通过酯化反应形成。磷酸酯键具有高度稳定性、生物可降解性和一定的亲水性,且响应碱性磷酸酶(ALP)后会发生特异灵敏的断裂,在生物医学领域具有重要应用价值。文中阐述了磷酸酯键的合成机理和性质,重点突出了磷酸酯键基智能响应体系在细胞培养、骨修复、药物控释和生物探针等领域的研究进展,展望了磷酸酯键基智能响应体系的未来发展方向。

Phosphate ester bonds are involved in the synthesis of nucleic acid and cell membrane in human body.Phosphate ester bonds are formed by the esterification reaction between phosphoric acid or phosphoryl chloride and alcohol hydroxyl group.Phosphate ester bonds possess high stability,excellent biodegradability and certain hydrophilicity.Phosphate ester bonds could break in response to alkaline phosphatase(ALP),having an important value in biomedical application.In this review,the synthesis mechanism and properties of phosphate ester bonds were described.The research progress of phosphate ester bond based intelligent response system in cell culture,bone repair,drug control release and biological probe were highlighted.The future development potential of phosphate ester bond based intelligent response system was also proposed at last.