8例达妥昔单抗β所致不良反应的回顾性分析

A retrospective analysis of adverse drug reactions induced by dinutuximab beta in 8 patients

目的:分析达妥昔单抗β所致不良反应(adverse drug reaction,ADR)的发生情况及临床特点,为临床合理用药提供参考。方法:对我院2021年以来应用达妥昔单抗β发生不良反应的8例住院患者病例资料进行回顾性分析。结果:8例发生达妥昔单抗β相关不良反应中,临床主要表现为疼痛、发热、毛细血管渗漏综合征、腹泻、轻度过敏反应、肝病和血液学毒性,其中以发热最为常见。ADRs发生时间集中在3.5~7 d。结论:在临床合理使用达妥昔单抗β时,应提高临床工作者对达妥昔单抗β不良反应的监测,保障患者安全有效使用药物。

Objective:To study the occurrence situation and clinical characteristics of the adverse drug reactions(ADRs)associated with dinutuximab beta,so as to provide reference for rational clinical use of the drug.Methods:A total of 8 hospitalized patients with the ADRs associated with dinutuximab beta were collected in our hospital during the year of 2021 and further analyzed.Results:In the 8 ADR cases,the ADRs and clinical manifestations induced by dinutuximab beta mainly included pain,fever,diarrhea,capillary leak syndrome,hepatopathia and anemia.Fever is the most commonly discovered clinical manifestations.The median time of ADRs was 3.5~7 days.Conclusion:During the rational use of dituximab bela in clinical practice,clinicians and pharmacists should reinforce the monitoring of the ADRs of the drug in order to ensure its safety and efficacy of the clinical application in patients.