基于数据挖掘分析针刺治疗原发性痛经腧穴配伍规律

The acupoint compatibility rules of acupuncture in the treatment of primary dysmenorrhea based on data mining

目的采用关联规则和聚类分析技术,找出原发性痛经(primary dysmenorrhea,PDM)临床上最常用的腧穴及配伍规律,并分析得出穴位配伍新处方,优化针刺临床选穴方案。方法计算机检索PubMed、中国知网、万方、维普数据库与中国生物医学数据库,收集针刺治疗PDM的文献。搜索时间为从构建数据库开始至2021年8月31日。提取穴位处方,进行数据挖掘,运用软件分析,建立针刺治疗PDM数据库。结果共纳入符合标准文献165篇,腧穴处方136个,穴位71个。针灸治疗PDM最常见的腧穴主要以足太阴脾经、任脉、足太阳膀胱经、足阳明胃经和足少阴肾经的经穴为主;使用频次排前5位的腧穴为三阴交、关元、地机、气海、次髎;频次出现最高的穴位配伍是“三阴交、关元”,出现频次43次。结论经过系统聚类可得到治疗PDM的腧穴配伍新处方:三阴交、天枢、子宫、太冲配伍;地机、肾俞、神阙、中极、合谷配伍;归来、十七椎、气海配伍;足三里、次髎配伍;关元、血海配伍。

Objective To find out the most common clinical acupoints and compatibility rules of primary dysmenorrhea(PDM)by using association rules and cluster analysis techniques,and to analyze the new prescription of acupoints,and optimize the clinical selection scheme of acupuncture.Methods PubMed,CNKI,Wanfang,VIP databases and Chinese biomedical database were searched by computer to collect literatures on acupuncture treatment of PDM.The search period was conducted from the construction of the database until August312021.Acupoint prescription was extracted,data mining was performed,and software analysis was used to establish a PDM database for acupuncture treatment.Results A total of 165 standard documents,136 acupoint prescriptions and 71 acupoints were included.The most common acupoints for PDM were Taiyin spleen meridian of foot,Ren meridian,Taiyang bladder meridian of foot,Yangming stomach meridian of foot and Shaoyin kidney meridian of foot;the top five acupoints in the frequency of use were Sanyinjiao(SP6),Guanyuan(RN4),Diji(SP8),Qihai(RN6)and Ciliao(BL32);the acupoints with the highest frequency were"Sanyinjiao(SP6)and Guanyuan(RN4)",with the frequency of 43 times.Conclusion Through systematic clustering,new prescriptions for the compatibility of acupoints for PDM could be obtained:compatibility of Sanyinjiao(SP6),Tianshu(ST25),Zigong(EX-CA1)and Taichong(LR3);compatibility of Diji(SP8),Shenshu(BL23),Shenque(RN8),Zhongji(RN3)and Hegu(LI4);compatibility of Guilai(ST29),Shiqizhui(EX-B7)and Qihai(RN6);compatibility of Zusanli(ST36)and Ciliao(BL32);compatibility of Guanyuan(RN4)and Xuehai(SP10).