稳定期COPD患者体内维生素A缺乏与CYP3A5基因多态性相关性研究

Association between vitamin A deficiency and CYP3A5 gene polymorphism in patients with stable COPD

目的:探讨稳定期慢性阻塞性肺疾病(COPD)患者体内维生素A缺乏与CYP3A5基因多态性相关性.方法:对106名(39名COPD患者和67名健康受试者)进行了病例对照研究,以确定昆明汉族人群CYP3A5单核苷酸多态性与维生素A缺乏者COPD风险的相关性.结果:rs776746多态性与COPD易感性显著增加有关.分层分析表明,rs776746显著提高维生素A缺乏患COPD的风险.结论:昆明汉族人群CYP3A5基因rs776746位点与维生素A缺乏者COPD风险增加显著相关.

Objective To investigate the relationship between vitamin A deficiency and CYP3A5 gene polymorphism in patients with stable chronic obstructive pulmonary disease(COPD).Methods We carried out a case-control study of 106 individuals(39 COPD patients and 67 healthy subjects)to identify the correlation of CYP3A5 single nucleotide polymorphism with COPD in vitamin A deficiency risk in the Kunming Han population.Results The rs776746 polymorphism was associated with a significantly increased susceptibility to COPD.Stratified analysis showed that rs776746 significantly increased the risk of COPD due to vitamin A deficiency.Conclusion The rs776746 locus of CYP3A5 gene in Kunming Han population is significantly as-sociated with an increased risk of COPD in vitamin A deficient patients.