急性呼吸窘迫综合征患者血清CC-16表达与肺顺应性及预后的相关性研究

Correlation of serum CC-16 expression with lung compliance and prognosis in patients with acute respiratory distress syndrome

目的:探究急性呼吸窘迫综合征(ARDS)患者血清CC-16表达与肺顺应性及预后的相关性.方法:前瞻性选取2019年9月~2021年9月本院收治ARDS患者124例为研究对象,根据入院24h氧合指数评估结果将124例患者分为轻度组60例、中度组41例与重度组23例.比较不同病情程度、不同治疗时点CC-16水平与肺顺应性差异,并通过Pearson相关性分析CC-16水平与肺顺应性相关性.通过随访记录患者生存情况,Kaplan-Meier法绘制生存曲线,并采用ROC评估CC-16水平预测预后价值.结果:CC-16水平比较重度组>中度组>轻度组,肺顺应性比较重度组<中度组<轻度组.Pearson相关性结果显示,血清CC-16水平与肺顺应性呈负相关.ARDS患者CC-16水平比较治疗10d后<治疗7d后<治疗前,肺顺应性比较治疗10d后>治疗7d后>治疗前.随访28d显示,124例ARDS患者中存活75例(60.48%),死亡49例(39.52%).ROC曲线结果显示,治疗前血清CC-16水平、治疗5d后血清CC-16水平、治疗10d后血清CC-16水平预测ARDS患者死亡的AUC分别为0.770、0.940、0.762,均具有一定准确性.结论:急性呼吸窘迫综合征(ARDS)患者血清Cc16表达升高、肺顺应性降低,血清CC-16表达与肺顺应性呈反比,血清Cc16表达可作为ARDS患者预后预测指标.

Objective To explore the correlation of serum CC-16 expression with lung compliance and prognosis in patients with acute respiratory distress syndrome(ARDS).Methods 124 ARDS patients admitted to our hospital from September 2019 to September 2021 were prospectively selected as the research subjects.According to the 24-h oxygenation index evaluation results,the 124 patients were divided into mild group with 60 cases,moderate group with 41 cases and severe cases.Group of 23 cases.The differences between the level of CC-16 and lung compliance at different disease degrees and different treatment time points were compared,and the correlation between the level of CC-16 and lung compliance was analyzed by Pearson correlation.Survival of patients was recorded by follow-up,survival curve was drawn by Kaplan-Meier method,and CC-16 level was used to evaluate the prognostic value of CC-16.Results The level of CC-16 was compared with the severe group>moderate group>mild group,and the lung compliance was compared with the severe group<moderate group<mild group.Pearson correlation results showed that serum CC-16 level was negatively correlated with lung compliance.Comparison of CC-16 levels in ARDS patients after treatment for 10 days<after treatment for 7 days<before treatment,and comparison of lung compliance after treatment for 10 days>after treatment for 7 days>before treatment.Follow-up for 28 days showed that among the 124 ARDS patients,75(60.48%)survived and 49(39.52%)died.The results of the ROC curve showed that the AUCs of serum CC-16 levels before treatment,serum CC-16 levels after 5 days of treatment,and serum CC-16 levels after 10 days of treatment were 0.770,0.940,and 0.762,respectively,for predicting the death of ARDS patients,all with certain accuracy.Conclusion The expression of serum Cc16 increased and lung compliance decreased in ARDS patients.Serum Cc16 expression was inversely proportional to lung compliance.Serum CC-16 ex-pression could be used as a prognostic indicator for ARDS patients.