非甾体抗炎滴眼液在白内障超声乳化术后角膜水肿的应用

Application of non-steroidal anti-inflammatory eye drops in corneal edema after phacoemulsification

目的:探究非甾体抗炎滴眼液(普拉洛芬)在白内障超声乳化术后角膜水肿患者中的治疗效果.方法:选取我院2018年2月~2021年5月白内障超声乳化术后角膜水肿患者106例(106只眼),根据治疗方案不同分为观察组(n=53)和对照组(n=53).对照组采用妥布霉素地塞米松及重组牛碱性成纤维细胞生长因子滴眼液(rb-bFGF)滴眼液治疗;观察组在对照组基础上联合普拉洛芬滴眼液治疗.比较2组角膜水肿消退时间、术后不同时段最佳矫正视力、临床疗效及药物不良反应.结果:观察组角膜水肿平均消退时间为(4.02±2.69)d,短于对照组(5.11±3.24)d.其中术后第3天、第5天、第7天观察组水肿消退情况明显优于对照组;观察组术后第3天、第5天、第7天时段最佳矫正视力大于0.5病例数均高于对照组.观察组显效率(86.79%)明显高于对照组(67.92%);两组患者药物不良反应发生率比较差异无统计学意义.结论:非甾体抗炎滴眼液(普拉洛芬)在超乳白内障术后角膜水肿治疗中,疗效确切,可加速术后角膜水肿消退进程,有效促进患者视力恢复,且不良反应少.

Objective To explore the therapeutic effect of non-steroidal anti-inflammatory(praprofen)eye drops in pa-tients with corneal edema after cataract phacoemulsification surgery.Methods 106 patients(106 eyes)with corneal edema after cataract phacoemulsification in our hospital from February 2018 to May 2021 were divided into observation group(n=53)and control group(n=53).After surgery,the control group was treated with tobramycin dexamethasone and recombinant bovine basic fibroblast growth factor eye drops(rb-bFGF).On the basis of the above,the observation group was treated with praprofen eye drops.The regression time of corneal edema,the number of cases with best corrected visual acuity more than 0.5 in different periods after operation,clinical efficacy and adverse drug reactions were compared between the two groups.Results The average regression time of corneal edema in the observation group was 4.02±2.69 days,which was significantly shorter than that in the control group(5.11±3.24 days).There was significant difference between the two groups.The regression of edema in the observation group was significantly better than that in the control group on the 3rd,5th and 7th day after operation,and there was significant difference between the two groups.On the 3rd,5th and 7th day after operation,the number of cases with best corrected visual acuity>0.5 in the observation group was higher than that in the control group.The markedly effective rate of the observation group(86.79%)was significantly higher than that of the control group(67.92%).There was no significant differ-ence in the incidence of adverse drug reactions between the two groups.Conclusion Non-steroidal anti-inflammatory(praprofen)eye drops are effective in the treatment of corneal edema after phacoemulsification and cataract surgery.