血清Periostin蛋白、肝细胞生长因子及N-proBNP对慢性心衰患者心血管事件的预测价值

Predictive value of serum Periostin protein,hepatocyte growth factor and N-proBNP for cardiovascular events in patients with chronic heart failure

目的:探究血清Periostin蛋白、肝细胞生长因子及N-proBNP对慢性心衰患者心血管事件的预测价值.方法:选取本院于2017年4月~2021年4月收治的慢性心衰患者160例,收集患者的临床一般资料并进行半年的随访,以随访期间患者是否发生心脑血管疾病分为对照组(未发生)和观察组(发生)两组,对发生心脑血管疾病的影响因素进行分析,并针对患者的血清Periostin蛋白、肝细胞生长因子(HGF)及N末端脑钠肽前体(N-proBNP)单一及联合对发生心血管疾病的预测价值进行分析.结果:观察组患者Periostin蛋白、HGF及NT-proBNP水平均显著高于对照组;Periostin蛋白、HGF及NT-proBNP是慢性心衰心血管事件发生的独立影响因素;Periostin蛋白对心血管事件发生的预测效能:AUC为0.928,灵敏度为0.860,特异度为0.833,HGF对心血管事件发生的预测效能上述指标分别为0.965,0.930,0.917,NT-proBNP对心血管事件发生的预测效能上述指标分别为0.905,0.920,0.767,而三者联合对心血管事件发生的预测效能上述指标为0.991,0.990,0.933.结论:慢性心衰心血管事件发生患者的Periostin蛋白、HGF及NT-proBNP指标水平显著高于未发生心血管事件的患者,且三者慢性心衰患者发生心血管事件的独立影响因素,同时三者均能单独对慢性心衰患者心血管事件发生情况进行预测,且三者联合时能更准确地对心血管事件发生情况进行预测.

Objective To explore the predictive value of serum Periostin protein,hepatocyte growth factor and N-proBNP for cardiovascular events in patients with chronic heart failure.Methods 160 patients with chronic heart failure treated in our hospital from April 2017 to April 2021 were selected.The clinical general data of the patients were collected and followed up for half a year.According to whether the patients had cardiovascular and cerebrovascular diseases during the follow-up period,they were divided into two groups:control group(no occurrence)and observation group(occurrence).The influencing factors of cardiovascular and cerebrovascular diseases were analyzed,and the serum Periostin protein,hepatocyte growth factor(HGF)and N-terminal pro-brain natriuretic peptide(N-terminal pro-brain natriuretic peptide).Results The levels of Periostin protein,HGF and NT-proBNP in the observation group were significantly higher than those in the control group.Periostin protein,HGF and NT-proBNP are independ-ent influencing factors of cardiovascular events in chronic heart failure.The predictive efficacy of Periostin protein for cardiovas-cular events:AUC is 0.928,sensitivity is 0.860,specificity is 0.833,HGF’s predictive efficacy for cardiovascular events is 0.965,0.930,0.917,and NT-proBNP’s predictive efficacy for cardiovascular events is 0.905,0.920,0.767,respectively.The predictive efficacy of the combination of the three for cardiovascular events was 0.991,0.990,0.933.Conclusion The levels of periodin pro-tein,HGF and NT proBNP in patients with cardiovascular events in chronic heart failure are significantly higher than those in pa-tients without cardiovascular events,and they are independent influencing factors of cardiovascular events in patients with chronic heart failure.At the same time,they can predict the occurrence of cardiovascular events in patients with chronic heart failure alone,and they can predict the occurrence of cardiovascular events more accurately when combined.