T1mapping技术在锰中毒神经系统检查中的应用研究

Application of MRI T1mapping technique in nervous system examination of manganese poisoning

目的使用磁共振成像(MRI)T1mapping技术对慢性锰中毒患者双侧尾状核头、壳核、苍白球、丘脑和胼地体进行定量分析,寻求该技术在锰中毒神经系统检查中的应用价值。方法对24例慢性锰中毒患者和36例对照组受试者进行颅脑MRI检查,采用BrainQuant序列生成T1mapping图像,测量双侧尾状核头、壳核、苍白球、丘脑和胼胝体一定范围感兴趣区(ROI)T1值,并进行比较。结果慢性锰中毒组患者双侧尾状核头、壳核、苍白球、丘脑ROI区T1值均低于对照组(P<0.05),慢性锰中毒组患者胼胝体ROI区T1值与对照组大致相当(P>0.05)。结论T1mapping技术可用于慢性锰中毒患者的辅助诊断和鉴别,具有较好的应用前景。

Objective The caudate nucleus head,putamen,globus pallidus,thalamus and corpus callosum of bilateral caudate nuclei in patients with chronic manganese poisoning by magnetic resonance imaging(MRI)T1mapping technique were quantitatively analyzed to explore the application value of this technique in the examination of nervous system of manganese poisoning cases.Methods A total of 24 patients with chronic manganese poisoning and 36 subjects in the control group were examined by MRI.T1mapping images were generated by Brain Quant sequence.T1 values of the head of bilateral caudate nucleus head,putamen,globus pallidus,thalamus and corpus callosum were measured and compared.Results The T1 values of the caudate nucleus head,putamen,globus pallidus and thalamus in the chronic manganese poisoning group were lower than those in the control group(P<0.05).The T1 values of ROI in the corpus callosum of patients with chronic manganese poisoning were approximately the same as that of the control group(P>0.05).Conclusions T1mapping technique can be used in the auxiliary diagnosis and differentiation of patients with chronic manganese poisoning,and has a good application prospect.