家禽m6A修饰研究进展

Research progress of N6-methyladenosine modification in poultry

N6-甲基腺嘌呤(m6A)作为一种重要的RNA表观遗传修饰方式,在真核生物基因组中广泛分布,已被证实在细胞分化、配子发生、脂肪沉积及肿瘤发生等生命过程中发挥重要作用。随着高通量检测技术和单碱基检测技术的快速发展,大量的m6A修饰调控蛋白被鉴定出来,相应的调控机理也得到了更深入的解析。文章综述了m6A的发现和特征、调控酶系统、检测技术、主要生物学功能及在家禽方面的研究进展,以期为后续对家禽m6A修饰的研究及应用提供理论支撑。

N6-methyladenine(m6 A), as an important RNA epigenetic modification method, is widely distributed in the genome of eukaryotes and has been proved to play an important role in cell differentiation, gametogenesis, fat deposition and tumorigenesis. With the rapid development of next generation sequencing(NGS) and single-base detection technology, a large number of m6 A modified regulatory proteins have been identified, and the corresponding regulatory mechanism has been further analyzed. In this article, the discovery and characteristics of m6 A, regulatory enzyme systems, detection techniques, main biological functions, and research progress in poultry were reviewed, in order to provide theoretical support for subsequent m6 A studies and applications of m6 A methylation modification in poultry.