铁死亡:缺血性卒中治疗的新靶点

Ferroptosis: a new target for the treatment of ischemic stroke

铁死亡是一种新型程序性细胞死亡,与缺血性卒中的病理生理学过程密切相关。铁死亡抑制剂可改善脑缺血后神经功能,提供神经保护。因此,铁死亡在缺血性卒中中的作用以及调控铁死亡干预缺血性卒中的发生和发展已成为研究热点。文章对缺血性卒中时铁死亡的分子机制以及潜在的治疗靶点进行了综述,期望为缺血性卒中的治疗提供新的视角。

Ferroptosis is a new type of programmed cell death that is closely associated with the pathophysiological process of ischemic stroke.Ferroptosis inhibitors can improve neurological function and provide neuroprotection after cerebral ischemia.Therefore,the role of ferroptosis in ischemic stroke and the regulation of ferroptosis to intervene in the occurrence and development of ischemic stroke have become a research hotspot.This article reviews the molecular mechanism and potential therapeutic targets of ferroptosis during ischemic stroke,hoping to provide new perspectives for the treatment of ischemic stroke.