肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展

Research progress on the function of surfactant protein-D and its role in the common lung diseases

肺表面活性蛋白-D(SP-D)是凝集素家族糖蛋白,主要在肺部的肺泡Ⅱ型上皮细胞和无纤毛细支气管上皮细胞合成和分泌,储存在Clara细胞的分泌颗粒中。SP-D是表面结合蛋白之一,也是组成肺表面活性系统的一部分。SP-D除了有助于肺泡空间内表面活性剂池稳态外,还具有宿主防御和免疫调节功能。本文通过对近年来SP-D在肺部常见疾病中的部分相关研究进行总结,为众多肺部疾病,特别是肺部炎症性疾病潜在的治疗提供重要的方法理论基础。

Lung surfactant protein D(SP-D)is a glycoprotein of the lectin family.In lungs it is synthesized and secreted mainly in the alveolar typeⅡepithelial cells and non-ciliated bronchiole epithelial cells,and are stored in secretory granules of Clara cells.SP-D is one of the surfactant binding proteins and is also a part of the pulmonary surfactant system.In addition to contributing to the homeostasis of surfactant pools in alveolar space,SP-D also exhibits functions of host defense and immunoregulation.This paper summarizes some relevant studies on SP-D in acute lung diseases in recent years,providing important theoretical basis for the potential treatment of many lung diseases,especially in inflammatory lung diseases.